Showing papers by "Alan Davison published in 1987"
TL;DR: In this article, the properties of TcOCl 4 O (4-x ) and Na[TcO(OCH 2 CH 2 O) 2 ] (2 ) have been determined by standard methods and refined to R 1 = 0.0694, R 2 =0.0613, on the basis of 2887 independent reflections.
35 citations
22 Jan 1987-International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology
TL;DR: The method involves admixing in a suitable first solvent in a container a target seeking ligand or salt or metal adduct thereof, a radionuclide label, and a reducing agent for said radion Euclide.
7 citations
TL;DR: In this article, the properties of TcOCl 4 O (4-x ) and Na[TcO(OCH 2 CH 2 O) 2 ] (2 ) have been determined by standard methods and refined to R 1 = 0.0694, R 2 =0.0613, on the basis of 2887 independent reflections.
Abstract: The complexes (Bu 4 N)[TcO(O 2 C 6 H 4 ) 2 ] ( 1 ) and Na[TcO(OCH 2 CH 2 O) 2 ] ( 2 ) have been prepared by reacting TcOCl 4 - with respective diols in methanol. Compound 2 was identified by its elemental analysis and field desorption mass spectrum. Crystals of compound 1 are monoclinic, C 2/ c , with cell dimensions a = 10.393(3), b = 13.835(3), c = 20.643(5) A, β = 101.74(3)° and four formula units in the unit cell. The crystal structure was determined by standard methods and refined to R 1 = 0.0694, R 2 = 0.0613, on the basis of 2887 independent reflections. The data were collected with use of Mo Kα radiation and a Syntex P 2 1 diffractometer. The anion of 1 is square pyramidal with a short TcO(oxo) bond (1.648(5) A). TcO distances to the diolate groups are longer (1.956(3), 1.958(3) A). The technetium atom lies 0.7014(4) A out of the plane of the four diolate oxygen atoms. Compound 2 is hydrolytically unstable in pure water, but can be stabilized by the addition of a several-fold molar excess of ethylene glycol. Compound 1 decomposes minimally in pure water after 24 h. These complexes are shown to be good structural models for 99m Tc-radiopharmaceuticals containing purely oxygen-donor ligands. Comparison of the physical properties of the structurally characterized members of the series of complexes with core structures TcOS x O (4- x ) ( x = O, 2, 4) shows a shift to low energy in the frequency of the terminal oxygen-technetium band in the IR correlated with increasing softness of the basal plane donor atom set.
2 citations
1 citations
TL;DR: In this article, a series of functionalized cholesteryl derivatives were synthesized and various lipophilic protein modification agents were analyzed for their protein binding ability, and the binding of human IgG, labeled with 125I, to modified phospholipid vesicles was ascertained.
Abstract: A series of functionalized cholesteryl derivatives were synthesized. The various lipophilic protein modification agents were analyzed for their protein binding ability. The binding of human IgG, labeled with 125I, to modified phospholipid vesicles was ascertained. Two agents performed well. These were cholest-5-en-3 beta-yl 5-carboxypentyl ether succinimido ester and cholest-5-en-3 beta-yl 6-carboxyhexyl ether succinimido ester.