Showing papers by "Alan H. Morris published in 1998"
TL;DR: The Round Table on Acute Lung Injury proved a stimulating forum for the interchange of ideas regarding the state of the field and afforded many opportunities for scientific interaction — both during and outside the formal program.
32 citations
TL;DR: Clinicians need to be aware of venous and arterial gas embolism as a complication of mechanical ventilation when treating a 53-year-old woman with ARDS who required positive pressure ventilation with positive end-expiratory pressure.
29 citations
TL;DR: A high level of user compliance with this protocol was achieved and the methods described herein to monitor compliance and reasons for noncompliance within a protocol are reusable in the domain of mechanical ventilation and possibly in other domains.
26 citations
TL;DR: The present data suggest that CPMG 72 measurements can consistently detect the presence of lung injury even when conventional histologic, morphometric, and gravimetric studies provide negative or equivocal results, and that the CMPG T2 method is superior, in this respect, to the Hahn decay method.
Abstract: The effects of endotoxin injury on lung NMR relaxation times (T1, CPMG T2, and Hahn decay constant (Hahn T2)) were studied in excised unperfused rat lungs. Blinded histologic examination showed no clear-cut separation between endotoxin and control lungs. Morphometric lung tissue volume density and gravimetric lung water content did not differ significantly between the two groups. In contrast, the values of the fast, intermediate, and slow T2 components, obtained by multiexponential analysis of the CPMG decay curve, increased markedly after endotoxin administration, with minimal overlap between endotoxin and control values. The response of Hahn T2 was, in general, in the same direction as that of CPMG 72; however, Hahn T2 may be more affected by measurement errors and may be less sensitive to the presence of lung injury. t1 showed minimal changes after injury. The present data suggest that CPMG 72 measurements can consistently detect the presence of lung injury even when conventional histologic, morphometric, and gravimetric studies provide negative or equivocal results, and that the CMPG T2 method is superior, in this respect, to the Hahn decay method. T1 does not appear to be sensitive to lung injury in the absence of significant lung water accumulation.
10 citations
Journal Article•
5 citations