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Alan J. Stewart
Researcher at University of St Andrews
Publications - 95
Citations - 3886
Alan J. Stewart is an academic researcher from University of St Andrews. The author has contributed to research in topics: Albumin & Serum albumin. The author has an hindex of 28, co-authored 81 publications receiving 2929 citations. Previous affiliations of Alan J. Stewart include Queen's University & Aristotle University of Thessaloniki.
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Structural and immunologic characterization of bovine, horse, and rabbit serum albumins.
Karolina A. Majorek,Przemyslaw J. Porebski,Arjun Dayal,Matthew D. Zimmerman,Kamila Jablonska,Alan J. Stewart,Maksymilian Chruszcz,Wladek Minor +7 more
TL;DR: In this paper, the crystal structures of albumins from cattle (BSA), horse (ESA) and rabbit (RSA) sera were analyzed in the context of their potential allergenicity and cross-reactivity.
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Albumin as a zinc carrier: properties of its high-affinity zinc-binding site
TL;DR: Comparisons of X-ray crystal structures of free and fatty-acid bound human serum albumin suggest that zinc binding to this site and fatty acid binding to one of the five major sites may be interdependent, and interactive binding of zinc and long-chain fatty acids to albumin may have physiological implications.
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Leptin and Obesity: Role and Clinical Implication
Milan Obradovic,Emina Sudar-Milovanovic,Sanja Soskic,Magbubah Essack,Swati Arya,Alan J. Stewart,Takashi Gojobori,Esma R. Isenovic +7 more
TL;DR: The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis.
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Interdomain zinc site on human albumin
TL;DR: Analysis of x-ray crystal structures of human albumin suggests that fatty acid binding to site 2 triggers a spring-lock mechanism, which disengages the upper and lower halves of the metal site, which provides a possible mechanism whereby fatty acids could influence the transport and delivery of zinc in blood.
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Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes.
TL;DR: How FFAs are altered in T2DM is reviewed and the likely downstream physiological and pathological implications of such changes are explored.