M
Matthew D. Zimmerman
Researcher at Rutgers University
Publications - 90
Citations - 3775
Matthew D. Zimmerman is an academic researcher from Rutgers University. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 28, co-authored 89 publications receiving 2893 citations. Previous affiliations of Matthew D. Zimmerman include University of Oxford & University of Virginia.
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Journal ArticleDOI
Structural and immunologic characterization of bovine, horse, and rabbit serum albumins.
Karolina A. Majorek,Przemyslaw J. Porebski,Arjun Dayal,Matthew D. Zimmerman,Kamila Jablonska,Alan J. Stewart,Maksymilian Chruszcz,Wladek Minor +7 more
TL;DR: In this paper, the crystal structures of albumins from cattle (BSA), horse (ESA) and rabbit (RSA) sera were analyzed in the context of their potential allergenicity and cross-reactivity.
Journal ArticleDOI
The association between sterilizing activity and drug distribution into tuberculosis lesions
Brendan Prideaux,Laura E. Via,Matthew D. Zimmerman,Seokyong Eum,Jansy Sarathy,Paul O'Brien,Chao Chen,Firat Kaya,Danielle M. Weiner,Pei-Yu Chen,Taeksun Song,Myungsun Lee,Tae Sun Shim,Jeong Su Cho,Wooshik Kim,Sang Nae Cho,Kenneth N. Olivier,Clifton E. Barry,Clifton E. Barry,Véronique Dartois +19 more
TL;DR: An alternative working model is proposed to prioritize new antibiotic regimens based on quantitative and spatial distribution of TB drugs in the major lesion types found in human lungs, and it is suggested that lesion penetration may contribute to treatment outcome.
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A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats.
Natalia Beloglazova,Natalia Beloglazova,Greg Brown,Greg Brown,Matthew D. Zimmerman,Matthew D. Zimmerman,Michael Proudfoot,Michael Proudfoot,Kira S. Makarova,M. Kudritska,M. Kudritska,M. Kudritska,Samvel Kochinyan,Samvel Kochinyan,Shuren Wang,Shuren Wang,Maksymilian Chruszcz,Maksymilian Chruszcz,Wladek Minor,Wladek Minor,Eugene V. Koonin,Aled M. Edwards,Aled M. Edwards,Aled M. Edwards,Alexei Savchenko,Alexei Savchenko,Alexei Savchenko,Alexander F. Yakunin,Alexander F. Yakunin +28 more
TL;DR: CAS2 proteins are sequence-specific endoribonucleases, and it is proposed that their role in the CRISPR-mediated anti-phage defense might involve degradation of phage or cellular mRNAs.
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Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo
Yancheng Liu,Shumin Tan,Lu Huang,Robert B. Abramovitch,Kyle H. Rohde,Matthew D. Zimmerman,Chao Chen,Véronique Dartois,Brian C. VanderVen,David G. Russell +9 more
TL;DR: Activation of Mycobacterium tuberculosis–infected macrophages in vitro and in vivo enhances drug tolerance and renders the bacilli more refractory to drug-dependent killing.
Journal ArticleDOI
Tuberculosis drugs’ distribution and emergence of resistance in patient’s lung lesions: A mechanistic model and tool for regimen and dose optimization
Natasha Strydom,Sneha V. Gupta,William S. Fox,Laura E. Via,Hyeeun Bang,Myungsun Lee,Seokyong Eum,Tae Sun Shim,Clifton E. Barry,Matthew D. Zimmerman,Véronique Dartois,Radojka M. Savic +11 more
TL;DR: The results suggest that the ability to reach and maintain therapeutic concentrations is both lesion and drug specific, indicating that stratifying patients based on disease extent, lesion types, and individual drug-susceptibility profiles may eventually be useful for guiding the selection of patient-tailored drug regimens and may lead to improved TB treatment outcomes.