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Alan J. Waring
Researcher at University of California, Los Angeles
Publications - 202
Citations - 9129
Alan J. Waring is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Pulmonary surfactant & Peptide. The author has an hindex of 55, co-authored 198 publications receiving 8568 citations. Previous affiliations of Alan J. Waring include Charles R. Drew University of Medicine and Science & Los Angeles Biomedical Research Institute.
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Journal ArticleDOI
Membrane thinning effect of the beta-sheet antimicrobial protegrin.
William T. Heller,Alan J. Waring,Robert I. Lehrer,Thad A. Harroun,Thomas M. Weiss,Lin Yang,Huey W. Huang +6 more
TL;DR: Results suggest that PG-1 has the same concentration-gated mechanism of action as alamethicin and the S state is adsorbed in the headgroup region of the lipid bilayer, where the peptide is in an inactive state.
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Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I
Brian J. Van Lenten,Alan C. Wagner,Chun-Ling Jung,Piotr Ruchala,Alan J. Waring,Robert I. Lehrer,Andrew D. Watson,Susan Hama,Mohamad Navab,Gattadahalli M. Anantharamaiah,Alan M. Fogelman +10 more
TL;DR: The results indicate that specific mimetic peptides have an increased binding affinity for oxidized phospholipids, compared with the parent nonoxidized phosphoattractant protein-1 (MCP-1) whereas full-length human apoA-I binds oxidized and nonoxids phospholIPids similarly.
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Activity of alpha- and theta-defensins against primary isolates of HIV-1.
Wei Wang,Sherry M. Owen,Donna L. Rudolph,Alexander M. Cole,Teresa Hong,Alan J. Waring,Renu B. Lal,Robert I. Lehrer +7 more
TL;DR: The relationship between carbohydrate-binding and the antiviral properties of α- and θ-defensins is compared and it is shown that the lectin-like behavior of defensins may contribute to many other activities of these multifunctional peptides.
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Effects of Lung Surfactant Proteins, SP-B and SP-C, and Palmitic Acid on Monolayer Stability
Junqi Ding,Dawn Y. Takamoto,Anja von Nahmen,Michael M. Lipp,Ka Yee C. Lee,Alan J. Waring,Joseph A. Zasadzinski +6 more
TL;DR: Langmuir isotherms and fluorescence and atomic force microscopy images of synthetic model lung surfactants were used to determine the influence of palmitic acid and synthetic peptides based on the surfactant-specific proteins SP-B and SP-C on the morphology and function of surfactan monolayers.
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CotH3 mediates fungal invasion of host cells during mucormycosis
Teclegiorgis Gebremariam,Mingfu Liu,Guanpingsheng Luo,Vincent M. Bruno,Quynh T. Phan,Alan J. Waring,John E. Edwards,Scott G. Filler,Michael R. Yeaman,Ashraf S. Ibrahim +9 more
TL;DR: Together, these data indicate that CotH3 and CotH2 function as invasins that interact with host cell GRP78 to mediate pathogenic host-cell interactions and identify CotH as a promising therapeutic target for mucormycosis.