P
Piotr Ruchala
Researcher at University of California, Los Angeles
Publications - 66
Citations - 3288
Piotr Ruchala is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Hepcidin & Peptide. The author has an hindex of 27, co-authored 65 publications receiving 2837 citations. Previous affiliations of Piotr Ruchala include University of California & Semel Institute for Neuroscience and Human Behavior.
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Journal ArticleDOI
Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload
Gloria C. Preza,Piotr Ruchala,Rogelio Pinon,Emilio Ramos,Bo Qiao,Michael A. Peralta,Shantanu Sharma,Alan J. Waring,Tomas Ganz,Elizabeta Nemeth +9 more
TL;DR: Modifications to increase resistance to proteolysis and oral bioavailability yielded minihepcidins that, after parenteral or oral administration to mice, lowered serum iron levels comparably to those after paretteral native hepcidin, which may be useful for the treatment of iron overload disorders.
Journal ArticleDOI
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models
György Biczó,Eszter T. Vegh,Natalia Shalbueva,Olga A. Mareninova,Jason M. Elperin,Ethan Lotshaw,Sophie Gretler,Aurelia Lugea,Sudarshan R. Malla,David W. Dawson,Piotr Ruchala,Julian P. Whitelegge,Samuel W. French,Li Wen,Sohail Z. Husain,Fred S. Gorelick,Péter Hegyi,Péter Hegyi,Zoltán Rakonczay,Ilya Gukovsky,Anna S. Gukovskaya +20 more
TL;DR: In different animal models, a central role is found for mitochondrial dysfunction, and for impaired autophagy as its principal downstream effector, in development of AP, a model of severe AP the pathogenesis of which has remained unknown.
Journal ArticleDOI
Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis.
Emilio Ramos,Piotr Ruchala,Julia B. Goodnough,Léon Kautz,Gloria C. Preza,Elizabeta Nemeth,Tomas Ganz +6 more
TL;DR: It is demonstrated that minihepcidins could be beneficial in iron overload disorders either used alone for prevention or possibly as adjunctive therapy with phlebotomy or chelation.
Journal ArticleDOI
Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I
Brian J. Van Lenten,Alan C. Wagner,Chun-Ling Jung,Piotr Ruchala,Alan J. Waring,Robert I. Lehrer,Andrew D. Watson,Susan Hama,Mohamad Navab,Gattadahalli M. Anantharamaiah,Alan M. Fogelman +10 more
TL;DR: The results indicate that specific mimetic peptides have an increased binding affinity for oxidized phospholipids, compared with the parent nonoxidized phosphoattractant protein-1 (MCP-1) whereas full-length human apoA-I binds oxidized and nonoxids phospholIPids similarly.
Journal ArticleDOI
Hepcidin-Induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio vulnificus
João Arezes,João Arezes,Grace Jung,Victoria Gabayan,Erika V. Valore,Piotr Ruchala,Paul A. Gulig,Tomas Ganz,Elizabeta Nemeth,Yonca Bulut +9 more
TL;DR: It is demonstrated that hepcidin-mediated hypoferremia is a host defense mechanism against siderophilic pathogens and suggested that hePCidin agonists may improve infection outcomes in patients with hereditary hemochromatosis or thalassemia.