A
Alan Sher
Researcher at National Institutes of Health
Publications - 508
Citations - 72497
Alan Sher is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Schistosoma mansoni & Immune system. The author has an hindex of 132, co-authored 486 publications receiving 68128 citations. Previous affiliations of Alan Sher include National Institute for Medical Research & University of Louisville.
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Innate recognition of Toxoplasma gondii in humans involves a mechanism distinct from that utilized by rodents.
TL;DR: This work identified CD16+ monocytes and DC1 dendritic cells as the major myeloid cell populations that respond to T. gondii in human peripheral blood and speculated that these marked distinctions in the pathways utilized for innate recognition of toxoplasma in mouse and man reflect the differing roles of the two hosts in the biology of this parasite.
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Strains and clones of Trypanosoma cruzi differ in their expression of a surface antigen identified by a monoclonal antibody
TL;DR: Data indicate that the epitope recognized by WIC 29.26 Ab is not present on all T. cruzi epimastigotes, and provide the first demonstration of clone-specific differences in a parasite antigen detected by a monoclonal antibody.
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Interleukin-12 can directly induce T-helper 1 responses in interferon-gamma (IFN-gamma) receptor-deficient mice, but requires IFN-gamma signalling to downregulate T-helper 2 responses.
Adrian P. Mountford,Patricia S. Coulson,Allen W. Cheever,Alan Sher,R. A. Wilson,Thomas A. Wynn +5 more
TL;DR: An in vivo model of pulmonary granuloma formation around embolized schistosome eggs was investigated as an environment in which to analyse a role for interleukin‐12 in the differentiation of T‐helper 1 (Th1) and Th2 subsets, and it is shown that IL‐12 can act independently of IFN‐γ to induce the development of Th1 cells.
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Heightened Plasma Levels of Heme Oxygenase-1 and Tissue Inhibitor of Metalloproteinase-4 as Well as Elevated Peripheral Neutrophil Counts Are Associated With TB-Diabetes Comorbidity
Bruno B. Andrade,Nathella Pavan Kumar,Rathinam Sridhar,Vaithilingam V. Banurekha,M. S. Jawahar,Thomas B. Nutman,Alan Sher,Subash Babu +7 more
TL;DR: Elevated plasma levels of HO-1 and TIMP-4 and peripheral blood neutrophil counts are potential single and combined markers of pathogenesis in TB and T2DM.
Journal Article
Induction of protective immunity against Schistosoma mansoni by a non living vaccine. I. Partial characterization of antigens recognized by antibodies from mice immunized with soluble schistosome extracts.
TL;DR: Results strongly suggest that anti-surface membrane reactivity is not required in the mechanism of protective immunity in this model, and soluble immunogens are likely to play a major role in the development of resistance in thismodel as immunogens and/or as targets of protective immune response.