A
Alan Sher
Researcher at National Institutes of Health
Publications - 508
Citations - 72497
Alan Sher is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Schistosoma mansoni & Immune system. The author has an hindex of 132, co-authored 486 publications receiving 68128 citations. Previous affiliations of Alan Sher include National Institute for Medical Research & University of Louisville.
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Mycobacterial antigen driven activation of CD14++CD16- monocytes is a predictor of tuberculosis-associated immune reconstitution inflammatory syndrome.
Bruno B. Andrade,Amrit Singh,G. Narendran,Melissa E. Schechter,Kaustuv Nayak,Sudha Subramanian,Selvaraj Anbalagan,Stig M. R. Jensen,Brian O. Porter,Lis Ribeiro do Valle Antonelli,Katalin A. Wilkinson,Robert J. Wilkinson,Graeme Meintjes,Helen van der Plas,Dean Follmann,Daniel L. Barber,Soumya Swaminathan,Alan Sher,Irini Sereti +18 more
TL;DR: Data point to a major role of mycobacterial antigen load and myeloid cell hyperactivation in the pathogenesis of TB-IRIS, and implicate monocytes and monocyte-derived cytokines as potential targets for TB- IRIS prevention or treatment.
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Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy.
Sivaranjani Namasivayam,Mamoudou Maiga,Mamoudou Maiga,Wuxing Yuan,Vishal Thovarai,Diego L. Costa,Lara R. Mittereder,Matthew F. Wipperman,Michael S. Glickman,Michael S. Glickman,Amiran Dzutsev,Giorgio Trinchieri,Alan Sher +12 more
TL;DR: This report provides the first detailed analysis of the longitudinal changes in the intestinal microbiota due to anti-tuberculosis therapy and establishes a murine model for studying the potential impact of this dysbiosis on host resistance and physiology.
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Toxoplasma gondii Triggers Myeloid Differentiation Factor 88-Dependent IL-12 and Chemokine Ligand 2 (Monocyte Chemoattractant Protein 1) Responses Using Distinct Parasite Molecules and Host Receptors
TL;DR: The results show for the first time that T. gondii possesses multiple molecules triggering distinct MyD88-dependent signaling cascades, that these pathways are independently regulated, and that they lead to distinct profiles of cytokine production.
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Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Schistosoma mansoni infected mice
TL;DR: A modified polymerase chain reaction (PCR) assay for analysis of cytokine gene expression from reverse-transcribed RNA obtained from small numbers of cells is described in detail and can be used successfully for studying differential expression of IL-10 in different microenvironments during infection of mice with Schistosoma mansoni.
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Passive transfer of acquired resistance to Schistosoma mansoni in laboratory mice.
TL;DR: Serum taken from mice 12-15 weeks after a primary infection of Schistosoma mansoni transfers to normal recipients a partial resistance to subsequent schistosome challenge, suggesting that humoral factors play a major role in the effector mechanism of schistOSome immunity.