Dragana Jankovic

TL;DR: The capacity of splenic DC but not MΦ to synthesize de novo high levels of IL-12 within hours of exposure to microbial products in vivo, as well as the ability of the same stimuli to induce migration of DC to the T cell areas, argues that DC function simultaneously as both antigen-presenting cells and IL- 12 producing accessory cells in the initiation of cell-mediated immunity to intracellular pathogens.

TL;DR: The data argue for a model in which IFN-γ gene regulation involves an autocrine loop, whereby the cytokine regulates a transcription factor that promotes its own production, and substantially alter the current view of T-bet in IFn-γ regulation and promotion of cell-mediated immune responses.

TL;DR: In this article, the source of regulatory IL-10 in mice infected with the protozoan parasite Toxoplasma gondii was analyzed and it was found that the same IFN-10(+)IFN-gamma(gamma) population displayed potent effector function against the parasite while, paradoxically, also inducing profound suppression of IL-12 production by antigen-presenting cells.

TL;DR: The data demonstrate that IL-23 and not IL-12 is essential for the development of maximal intestinal disease, and support a model in which IL- 23 drives both interferon γ and IL-17 responses that together synergize to trigger severe intestinal inflammation.

TL;DR: It is demonstrated here that both host resistance and T. gondii-induced IL-12 production are dramatically reduced in mice lacking the adaptor molecule MyD88, an important signaling element used by Toll-like receptor (TLR) family members.