S
Subash Babu
Researcher at National Institutes of Health
Publications - 212
Citations - 5811
Subash Babu is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Tuberculosis & Immune system. The author has an hindex of 35, co-authored 177 publications receiving 4584 citations. Previous affiliations of Subash Babu include Indian Council of Medical Research & Science Applications International Corporation.
Papers
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Journal ArticleDOI
Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
Katrin D. Mayer-Barber,Bruno B. Andrade,Sandra D. Oland,Eduardo P. Amaral,Eduardo P. Amaral,Daniel L. Barber,Jacqueline Gonzales,Steven C. Derrick,Ruiru Shi,Nathella Pavan Kumar,Wang Wei,Xing Yuan,Guolong Zhang,Ying Cai,Subash Babu,Subash Babu,Marta Catalfamo,Andres M. Salazar,Laura E. Via,Clifton E. Barry,Alan Sher +20 more
TL;DR: It is demonstrated that interleukin-1 (IL-1) confers host resistance through the induction of eicosanoids that limit excessive type I interferon (IFN) production and foster bacterial containment and it is established that host-directed immunotherapy with clinically approved drugs that augment prostaglandin E2 levels in these settings prevented acute mortality of Mtb-infected mice.
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Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence.
TL;DR: It is concluded that a profound impairment of live parasite-specific Th1 and Th2 immune responses occurs in lymphatic filariasis that is governed at the transcriptional level by a complex interplay of inhibitory mediators.
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S100A8/A9 Proteins Mediate Neutrophilic Inflammation and Lung Pathology during Tuberculosis
Radha Gopal,Leticia Monin,Diana Torres,Samantha Slight,Smriti Mehra,Kyle C. McKenna,Beth A. Fallert Junecko,Todd A. Reinhart,Jay K. Kolls,Renata Baez-Saldaña,Alfredo Cruz-Lagunas,Tatiana S. Rodriguez-Reyna,Nathella Pavan Kumar,Phillipe Tessier,Johannes Roth,Moisés Selman,Enrique Becerril-Villanueva,Javier Baquera-Heredia,Bridgette M. Cumming,Victoria O. Kasprowicz,Adrie J. C. Steyn,Subash Babu,Deepak Kaushal,Joaquín Zúñiga,Thomas Vogl,Javier Rangel-Moreno,Shabaana A. Khader +26 more
TL;DR: It is demonstrated that in human patients with active TB and in nonhuman primate models of M. tuberculosis infection, neutrophils producing S100 proteins are dominant within the inflammatory lung granulomas seen during active TB.
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Prevalence of SARS-CoV-2 infection in India: Findings from the national serosurvey, May-June 2020
Manoj V Murhekar,Tarun Bhatnagar,Sriram Selvaraju,Kiran Rade,V. Saravanakumar,Jeromie Wesley Vivian Thangaraj,Muthusamy Santhosh Kumar,Naman K. Shah,R. Sabarinathan,Alka Turuk,P. K. Anand,Smita Asthana,Rakesh Balachandar,Sampada Dipak Bangar,Avi Kumar Bansal,Jyothi Bhat,Debjit Chakraborty,Chethana Rangaraju,Vishal Chopra,Dasarathi Das,Alok Kumar Deb,Kangjam Rekha Devi,Gaurav Raj Dwivedi,S. Muhammad Salim Khan,Inaamul Haq,M. Sunil Kumar,Avula Laxmaiah,Madhuka,Amarendra Mahapatra,Anindya Mitra,A.R. Nirmala,Avinash Pagdhune,Mariya Amin Qurieshi,Tekumalla Ramarao,Seema Sahay,Y.K. Sharma,Marinaik Basavegowdanadoddi Shrinivasa,Vijay K. Shukla,Prashant Singh,Ankit Viramgami,Vimith Cheruvathoor Wilson,Rajiv Yadav,C. P. Girish Kumar,Hanna Elizabeth Luke,Uma Devi Ranganathan,Subash Babu,Krithikaa Sekar,Pragya D Yadav,Gajanan N. Sapkal,Aparup Das,Pradeep Das,Shanta Dutta,Rajkumar Hemalatha,Ashwani Kumar,Kanwar Narain,Somashekar Narasimhaiah,Samiran Panda,Sanghamitra Pati,Shripad A. Patil,Kamalesh Sarkar,Shalini Singh,Rajni Kant,Srikanth Tripathy,G S Toteja,Giridhara R Babu,Shashi Kant,J P Muliyil,Ravindra Mohan Pandey,Swarup Sarkar,Sujeet Kumar Singh,Sanjay Zodpey,Raman R. Gangakhedkar,Devarajulu Reddy,Balram Bhargava +73 more
TL;DR: Seroprevalence of SARS-CoV-2 was low among the adult population in India around the beginning of May 2020, and males, living in urban slums and occupation with high risk of exposure to potentially infected persons were associated with seropositivity.
Journal ArticleDOI
Increased Th1 and suppressed Th2 serum cytokine levels in subjects with diabetic coronary artery disease.
TL;DR: It appears that transition from T2DM or CAD to T2 DM-CAD co-morbidity is associated with strong down regulation of Th2 cytokines and enhancement of Th1 responses.