Alan Sher

TL;DR: This review focuses on the regulatory functions of IL-10 in the response to parasitic and bacterial infection revealed through knockout, cytokine/receptor blocking, and transgenic mouse studies.

TL;DR: A vaccine model based on induction of cell-mediated immunity and shown that it protects mice against Schistosoma mansoni infection is designed and verified, verifying the feasibility of a vaccine against schistosomiasis basedon induction ofcell-mediated immune resistance mechanisms.

TL;DR: Inbred P- and A-strain mice are deficient in their capacity to develop resistance to challenge infection in response to vaccination with irradiated cercariae of Schistosoma mansoni and are also defective in their cell-mediated response as assessed by the activity of antigen-elicited macrophages in killing schistosome larvae in vitro, but vaccinated mice displayed high levels of both immunity to challenge and macrophage larvicidal activity.

TL;DR: In this article , the cellular profile of Mycobacterium tuberculosis (Mtb)-specific T cells in pericardial fluid and peripheral blood was compared in patients with extra-pulmonary tuberculosis (EPTB) disease.

TL;DR: Although innate immunity has an important role in resistance to acute infections, it is the adaptive response, characterized by the selective expansion of T and B cells, that is required to provide long-term immunological control of many chronic parasitic infections.