Vito Quaranta

TL;DR: Cleavage of laminin-5 by MMP2 and the resulting activation of the Ln-5 cryptic site may provide new targets for modulation of tumor cell invasion and tissue remodeling.

TL;DR: A new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers is introduced, which is introduced for laminin trimers.

TL;DR: The genetic make-up of a cancer cell may realize its invasive potential through a clonal evolution process driven by definable microenvironmental selective forces, and this mathematical model provides a theoretical/experimental framework to quantitatively characterize this selective pressure for invasion and test ways to eliminate it.

TL;DR: Both cytoplasmic domains are required for energy-dependent, cell type-specific affinity modulation and mutations that disrupted a highly conserved alpha subunit GFFKR motif, resulted in high affinity binding of ligands to alpha IIb beta 3.

TL;DR: It is shown that exogenous addition of activated matrix metalloprotease (MMP) 2 stimulates migration onto Ln-5 in breast epithelial cells via cleavage of the γ2 subunit, and this model suggests a model whereby expression of MT1-MMP is the primary trigger for migration over LN-5, whereas MMP2, which is activated by MT1,MMP, may play an ancillary role, perhaps by amplifying the MT1