Albert Tauler

TL;DR: E2F1 emerges as a key protein that integrates cell division and growth, both of which are essential for cell proliferation, and is complementary in activating the signal pathway.

TL;DR: It is demonstrated that actinomycin D, at low concentrations, inhibits proliferation and induces cell death in vitro, as well as tumor regression in vivo and it is proposed that use of ribosome biogenesis inhibitors should be clinically considered as a potential therapy to treat neuroblastomas.

TL;DR: These studies identify a 40S ribosome function independent of those in translation that, with LARP1, mediates the autogenous control of 5′TOP mRNA stability, whose disruption is implicated in the pathophysiology of 5q− syndrome.

TL;DR: Findings on lysosomal trafficking, mTORC1 activation and autophagy suppression suggest that pharmacological intervention at the level of v-ATPase may be an efficacious avenue for the treatment of metastatic processes in tumors overexpressing E2F1.

TL;DR: All enzymes showed variations in their mRNA levels after the surgical stress, and the differences were more pronounced in regenerating liver than in sham-operated animals, being practically normalized at 24 h.