P
Pablo Menendez
Researcher at University of Barcelona
Publications - 286
Citations - 11889
Pablo Menendez is an academic researcher from University of Barcelona. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 54, co-authored 266 publications receiving 10424 citations. Previous affiliations of Pablo Menendez include University of Buenos Aires & Carlos III Health Institute.
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Journal ArticleDOI
Cytokines and BMP-4 promote hematopoietic differentiation of human embryonic stem cells.
Kristin Chadwick,Lisheng Wang,Li Li,Pablo Menendez,Barbara Murdoch,Anne Rouleau,Mickie Bhatia +6 more
TL;DR: This study establishes the first evidence for the role of cytokines and BMP-4 in promoting hematopoietic differentiation of hESC lines and provides an unprecedented system to study early developmental events that govern the initiation of hematoiesis in the human.
Journal ArticleDOI
IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro
Sean C. Bendall,Morag Stewart,Pablo Menendez,Dustin George,Kausalia Vijayaragavan,Tamra E. Werbowetski-Ogilvie,Verónica Ramos-Mejía,Anne Rouleau,Jiabi Yang,Marc Bossé,Gilles A. Lajoie,Mickie Bhatia +11 more
TL;DR: This study demonstrates a direct role of the IGF-II/IGF1R axis on human ES cell physiology and establishes that hdFs produced by human ES cells themselves define the stem cell niche of pluripotent human stem cells.
Journal ArticleDOI
The MLL recombinome of acute leukemias in 2017
Christian Meyer,Thomas Burmeister,Daniela Gröger,Grigory Tsaur,L Fechina,Aline Renneville,Rosemary Sutton,Nicola C. Venn,Mariana Emerenciano,Maria S. Pombo-de-Oliveira,C Barbieri Blunck,B Almeida Lopes,Jan Zuna,Jan Trka,Paola Ballerini,Hélène Lapillonne,M. De Braekeleer,Giovanni Cazzaniga,L Corral Abascal,V H J van der Velden,Eric Delabesse,T S Park,S H Oh,Maria Luiza Macedo Silva,T Lund-Aho,Vesa Juvonen,Andrew S. Moore,Olaf Heidenreich,Josef Vormoor,Elena Zerkalenkova,Yulia Olshanskaya,Clara Bueno,Clara Bueno,Pablo Menendez,Pablo Menendez,Andrea Teigler-Schlegel,U zur Stadt,Jana Lentes,Gudrun Göhring,Anatoly Kustanovich,Olga Aleinikova,Beat W. Schäfer,S Kubetzko,Hans O. Madsen,Bernd Gruhn,X Duarte,Paula Gameiro,Eric Lippert,A Bidet,J M Cayuela,Emmanuelle Clappier,Cristina N. Alonso,Christian M. Zwaan,M M van den Heuvel-Eibrink,Shai Izraeli,Shai Izraeli,L. Trakhtenbrot,L. Trakhtenbrot,P Archer,Jeremy Hancock,Anja Möricke,Julia Alten,Martin Schrappe,Martin Stanulla,Sabine Strehl,Andishe Attarbaschi,Michael Dworzak,Oskar A. Haas,Renate Panzer-Grümayer,Lukasz Sedek,Tomasz Szczepański,Aurélie Caye,L Suarez,Hélène Cavé,Rolf Marschalek +74 more
TL;DR: This study provides a comprehensive analysis of the MLL recombinome in acute leukemia and demonstrates that the establishment of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.
Journal ArticleDOI
The MLL recombinome of acute leukemias in 2013
Claus Meyer,Julia Hofmann,Thomas Burmeister,Daniela Gröger,T S Park,Mariana Emerenciano,M. Pombo De Oliveira,Aline Renneville,Patrick Villarese,Elizabeth Macintyre,Hélène Cavé,Emmanuelle Clappier,K. Mass-Malo,Jan Zuna,Jan Trka,E De Braekeleer,M. De Braekeleer,S H Oh,Grigory Tsaur,L Fechina,V H J van der Velden,J J M van Dongen,Eric Delabesse,Renata Binato,Mara Silva,AM Kustanovich,Olga V. Aleinikova,Marian H. Harris,T Lund-Aho,Vesa Juvonen,Olaf Heidenreich,Josef Vormoor,William W.L. Choi,Marie Jarošová,A. Kolenova,Clara Bueno,Pablo Menendez,S. Wehner,Cornelia Eckert,Pascaline Talmant,Sylvie Tondeur,Eric Lippert,E. Launay,Catherine Henry,Paola Ballerini,H. Lapillone,Mary Callanan,Jean Michel Cayuela,Charles Herbaux,Giovanni Cazzaniga,P. M. Kakadiya,Stefan K. Bohlander,Martina Ahlmann,Jong Rak Choi,Paula Gameiro,Dongsoon Lee,Juergen Krauter,Pascale Cornillet-Lefebvre,G te Kronnie,Beat W. Schäfer,S. Kubetzko,Cristina N. Alonso,U. Zur Stadt,Rosemary Sutton,N. C. Venn,Shai Izraeli,Luba Trakhtenbrot,H. O. Madsen,P. Archer,Jeremy Hancock,Nuno Cerveira,Manuel R. Teixeira,L Lo Nigro,Anja Möricke,Martin Stanulla,Martin Schrappe,Lukasz Sedek,Tomasz Szczepański,Christian M. Zwaan,Eva A. Coenen,M.M. van den Heuvel-Eibrink,Sabine Strehl,Michael Dworzak,Renate Panzer-Grümayer,Theodor Dingermann,Thomas Klingebiel,Rolf Marschalek +86 more
TL;DR: Long-distance inverse-polymerase chain reaction was used to characterize the chromosomal rearrangement of individual acute leukemia patients and revealed a total of 121 different MLL rearrangements, of which 79 TPGs are now characterized at the molecular level.
Journal ArticleDOI
Endothelial and Hematopoietic Cell Fate of Human Embryonic Stem Cells Originates from Primitive Endothelium with Hemangioblastic Properties
Lisheng Wang,Li Li,Farbod Shojaei,Farbod Shojaei,Krysta Levac,Chantal Cerdan,Pablo Menendez,Tanya Martin,Anne Rouleau,Mickie Bhatia,Mickie Bhatia +10 more
TL;DR: It is suggested that human hematopoiesis and endothelial maturation originate exclusively from a subset of embryonic endothelium that possesses hemangioblastic properties and offers a model system to study these lineage relationships in the human.