A
Alberto M. Martelli
Researcher at University of Bologna
Publications - 61
Citations - 2361
Alberto M. Martelli is an academic researcher from University of Bologna. The author has contributed to research in topics: Nuclear matrix & Phospholipase C. The author has an hindex of 27, co-authored 61 publications receiving 2308 citations. Previous affiliations of Alberto M. Martelli include Nuclear Regulatory Commission & University of Trieste.
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Journal ArticleDOI
Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy
James A. McCubrey,Linda S. Steelman,Steve L. Abrams,Fred E. Bertrand,D. E. Ludwig,Jörg Bäsecke,Massimo Libra,Franca Stivala,M. Milella,Agostino Tafuri,Paolo Lunghi,Antonio Bonati,Alberto M. Martelli,Alberto M. Martelli +13 more
TL;DR: It may be possible to combine various chemotherapeutic and antibody-based therapies with low molecular weight, cell membrane-permeable inhibitors which target the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to ultimately suppress the survival pathways, induce apoptosis and inhibit leukemic growth.
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The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system
TL;DR: The most updated findings about PI3Ks, their lipid products, and Akt in relationship with the nuclear compartment are summarized and an overview of the possible mechanisms by which they regulate important cell functions are provided.
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Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts
P. L. Tazzari,Alessandra Cappellini,Francesca Ricci,Camilla Evangelisti,Veronica Papa,Tiziana Grafone,Giovanni Martinelli,Roberto Conte,Lucio Cocco,James A. McCubrey,Alberto M. Martelli,Alberto M. Martelli +11 more
TL;DR: Evidence is presented that MRP1, but not P-gp, expression is under the control of the PI3K/Akt axis in AML blasts, and data suggest that PI3k/AKT activation may lead to the development of chemoresistance inAML blasts through a mechanism involving a p53-dependent suppression of MRP 1 expression.
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Translocation of Akt/PKB to the nucleus of osteoblast-like MC3T3-E1 cells exposed to proliferative growth factors
Paola Borgatti,Alberto M. Martelli,Alfonso Bellacosa,Alfonso Bellacosa,Riccardo Casto,Leo Massari,Silvano Capitani,Luca M. Neri,Luca M. Neri +8 more
TL;DR: The findings strongly suggest that the intranuclear translocation of Akt/PKB is an important step in signalling pathways that mediate cell proliferation.
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Multiple biological responses activated by nuclear protein kinase C.
TL;DR: A wealth of data is being accumulated, demonstrating that nuclear protein kinase C isoforms are involved in the regulation of several critical biological functions such as cell proliferation and differentiation, neoplastic transformation, and apoptosis.