J
Jörg Bäsecke
Researcher at University of Göttingen
Publications - 51
Citations - 7051
Jörg Bäsecke is an academic researcher from University of Göttingen. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Protein kinase B. The author has an hindex of 29, co-authored 50 publications receiving 6411 citations.
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Journal ArticleDOI
Roles of the raf/mek/erk pathway in cell growth, malignant transformation and drug resistance
James A. McCubrey,Linda S. Steelman,William H. Chappell,Stephen L. Abrams,Ellis W.T. Wong,Fumin Chang,Brian D. Lehmann,David M. Terrian,Michele Milella,Agostino Tafuri,Franca Stivala,Massimo Libra,Jörg Bäsecke,Camilla Evangelisti,Alberto M. Martelli,Richard A. Franklin +15 more
TL;DR: The Raf/MEK/ERK pathway has different effects on growth, prevention of apoptosis, cell cycle arrest and induction of drug resistance in cells of various lineages which may be due to the presence of functional p53 and PTEN and the expression of lineage specific factors.
Journal ArticleDOI
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
Linda S. Steelman,William H. Chappell,Stephen L. Abrams,C. Ruth Kempf,Jacquelyn M. Long,Piotr Laidler,Sanja Mijatović,Danijela Maksimović-Ivanić,Franca Stivala,Maria Clorinda Mazzarino,Marco Donia,Paolo Fagone,Graziella Malaponte,Ferdinando Nicoletti,Massimo Libra,Michele Milella,Agostino Tafuri,Antonio Bonati,Jörg Bäsecke,Lucio Cocco,Camilla Evangelisti,Alberto M. Martelli,Giuseppe Montalto,Melchiorre Cervello,James A. McCubrey +24 more
TL;DR: The functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli are discussed and the recently described roles of these pathways in cancer stem cells, cellular senescence and aging are evaluated.
Journal ArticleDOI
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
William H. Chappell,Linda S. Steelman,Jacquelyn M. Long,Ruth C. Kempf,Stephen L. Abrams,Richard A. Franklin,Jörg Bäsecke,Franca Stivala,Marco Donia,Paolo Fagone,Graziella Malaponte,Maria Clorinda Mazzarino,Ferdinando Nicoletti,Massimo Libra,Danijela Maksimović-Ivanić,Sanja Mijatović,Giuseppe Montalto,Melchiorre Cervello,Piotr Laidler,Michele Milella,Agostino Tafuri,Antonio Bonati,Camilla Evangelisti,Lucio Cocco,Alberto M. Martelli,James A. McCubrey +25 more
TL;DR: This review will evaluate more recently described potential uses of MEK, PI3K, Akt and mTOR inhibitors in the proliferation of malignant cells, suppression of CICs, cellular senescence and prevention of aging.
Journal ArticleDOI
GSK-3 as potential target for therapeutic intervention in cancer.
James A. McCubrey,Linda S. Steelman,Fred E. Bertrand,Nicole Marie Davis,Melissa L. Sokolosky,Stephen L. Abrams,Giuseppe Montalto,Antonino B. D'Assoro,Massimo Libra,Ferdinando Nicoletti,Roberta Maestro,Jörg Bäsecke,Dariusz Rakus,Agnieszka Gizak,Zoya N. Demidenko,Lucio Cocco,Alberto M. Martelli,Melchiorre Cervello +17 more
TL;DR: This review will focus on the diverse roles that GSK-3 plays in various human cancers, in particular in solid tumors, and how this pivotal kinase interacts with multiple signaling pathways.
Journal ArticleDOI
Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia
Linda S. Steelman,Steve L. Abrams,Jarrett T. Whelan,Fred E. Bertrand,D. E. Ludwig,Jörg Bäsecke,Massimo Libra,Franca Stivala,M. Milella,Agostino Tafuri,Paolo Lunghi,Antonio Bonati,Alberto M. Martelli,James A. McCubrey +13 more
TL;DR: The Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT signaling cascades are described and recent data regarding the regulation and mutation status of these pathways and their involvement in leukemia are summarized.