A
Aleš Macela
Researcher at Military Medical Academy
Publications - 41
Citations - 998
Aleš Macela is an academic researcher from Military Medical Academy. The author has contributed to research in topics: Francisella tularensis & Proteome. The author has an hindex of 17, co-authored 40 publications receiving 985 citations. Previous affiliations of Aleš Macela include Health Science University.
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Journal ArticleDOI
The immunomodulatory effect(s) of lead and cadmium on the cells of immune system in vitro.
TL;DR: The results suggest the metal-induced changes in immunoregulatory mechanism of host with potentially severe clinical consequences.
Journal ArticleDOI
The analysis of S100A9 and S100A8 expression in matched sets of macroscopically normal colon mucosa and colorectal carcinoma: the S100A9 and S100A8 positive cells underlie and invade tumor mass.
Jiří Stulík,Jan Österreicher,Kamila Koupilova,Jiří Knížek,Aleš Macela,Jan Bures,Jandík P,František Langr,Karel Dědič,Peter R. Jungblut +9 more
TL;DR: The level of S100A9 protein, in comparison with matched normal colon mucosa, was significantly increased in malignant tissues of 16 patients (70%) and an additional protein, identified by matrix‐assisted laser desorption/ionization ‐ mass spectrometry (MALDI‐MS) as S 100A8, exhibited an increased expression in the same specimens of malignant tissue as the S100 a9 protein.
Journal ArticleDOI
Mapping of immunoreactive antigens of Francisella tularensis live vaccine strain
Jana Havlasová,Lenka Hernychová,Petr Halada,Vera Pellantova,Jan Krejsek,Jiri Stulik,Aleš Macela,Peter R. Jungblut,Pär Larsson,Mats Forsman +9 more
TL;DR: Comprehensive mapping of immunoreactive antigens using the attenuated live vaccine strain of F. tularensis LVS originating from the European virulent strain finds that 60 kDa and 10 kDa chaperonins that occurred in several charge and mass variants, predominated.
Journal ArticleDOI
Proteome study of colorectal carcinogenesis.
Jiri Stulik,Lenka Hernychová,Stanislava Porkertová,Jiri Knizek,Aleš Macela,Bures J,Jandík P,Jim I. Langridge,Peter R. Jungblut +8 more
TL;DR: The alterations in the expression of nine proteins were common for both precancerous and neoplastic tissues suggesting their role in colon tumorigenesis, and 18 were annotated by mass spectrometry.
Journal ArticleDOI
Protein abundance alterations in matched sets of macroscopically normal colon mucosa and colorectal carcinoma.
Jiri Stulik,Kamila Koupilova,Jan Österreicher,Jiri Knizek,Aleš Macela,Bures J,Jandík P,František Langr,Karel Dedic,Peter R. Jungblut +9 more
TL;DR: It is concluded that the proteomic approach is useful for the study of complex biological events underlying the process of colorectal tumorigenesis.