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Alessandra Siracusano
Researcher at Istituto Superiore di Sanità
Publications - 67
Citations - 2768
Alessandra Siracusano is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Echinococcus granulosus & Antigen. The author has an hindex of 31, co-authored 67 publications receiving 2567 citations.
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Journal ArticleDOI
Modulation of Human Immune Response by Echinococcus granulosus Antigen B and Its Possible Role in Evading Host Defenses
Rachele Riganò,Elisabetta Profumo,Fabrizio Bruschi,Giovanni Carulli,Antonio Azzara,S. Ioppolo,Brigitta Buttari,Elena Ortona,Paola Margutti,Antonella Teggi,Alessandra Siracusano +10 more
TL;DR: Findings confirm that AgB plays a role in the escape from early immunity by inhibiting PMN chemotaxis and add new information on the host-parasite relationship, suggesting thatAgB exploits the activation of T helper cells by eliciting a nonprotective Th2 cell response.
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Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell response.
Rachele Riganò,Brigitta Buttari,Elisabetta Profumo,Elena Ortona,Federica Delunardo,Paola Margutti,Vincenzo Mattei,Antonella Teggi,Maurizio Sorice,Alessandra Siracusano +9 more
TL;DR: Results suggest that E. granulosus escapes host immunosurveillance in two ways: by interfering with monocyte differentiation and by modulating DC maturation.
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Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story
TL;DR: In vitro and in vivo immunological approaches, together with molecular biology and immunoproteomic technologies, provided exciting insights into the mechanisms involved in the initiation of E. granulosus infection and the consequent induction and regulation of the immune response.
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Immunological markers indicating the effectiveness of pharmacological treatment in human hydatid disease
Rachele Riganò,Elisabetta Profumo,S. Ioppolo,S. Notargiacomo,Elena Ortona,Antonella Teggi,Alessandra Siracusano +6 more
TL;DR: In this paper, the authors evaluated the effectiveness of pharmacological treatment in human hydatid disease (Echinococcus granulosus infection) by using immunoblotting and ELISA.
Journal ArticleDOI
Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis
Elena Ortona,Rachele Riganò,Paola Margutti,Sergio Notargiacomo,S. Ioppolo,Sergio Vaccari,Stefano Barca,Brigitta Buttari,Elisabetta Profumo,Antonella Teggi,Alessandra Siracusano +10 more
TL;DR: The findings underline the need to standardize techniques and antigenic preparations and to improve the performance of immunodiagnosis by characterizing new antigens and detecting distinct immunoglobulin classes.