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Brigitta Buttari
Researcher at Istituto Superiore di Sanità
Publications - 93
Citations - 3101
Brigitta Buttari is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Immune system & Oxidative stress. The author has an hindex of 27, co-authored 75 publications receiving 2266 citations.
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Journal ArticleDOI
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
TL;DR: The relationship between Nrf2 signaling and the inflammation as well as possible approaches for the therapeutic modulation of this pathway are examined.
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Anti-β2-glycoprotein I antibodies induce monocyte release of tumor necrosis factor α and tissue factor by signal transduction pathways involving lipid rafts
Maurizio Sorice,Agostina Longo,Antonella Capozzi,Tina Garofalo,Roberta Misasi,Cristiano Alessandri,Fabrizio Conti,Brigitta Buttari,Rachele Riganò,Elena Ortona,Guido Valesini +10 more
TL;DR: New insight is provided into the pathogenesis of APS and anti-β2GPI antibodies react with their target antigen, likely in association with annexin A2 and TLR-4, in lipid rafts in the monocyte plasma membrane, improving the knowledge of valuable therapeutic targets.
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Modulation of Human Immune Response by Echinococcus granulosus Antigen B and Its Possible Role in Evading Host Defenses
Rachele Riganò,Elisabetta Profumo,Fabrizio Bruschi,Giovanni Carulli,Antonio Azzara,S. Ioppolo,Brigitta Buttari,Elena Ortona,Paola Margutti,Antonella Teggi,Alessandra Siracusano +10 more
TL;DR: Findings confirm that AgB plays a role in the escape from early immunity by inhibiting PMN chemotaxis and add new information on the host-parasite relationship, suggesting thatAgB exploits the activation of T helper cells by eliciting a nonprotective Th2 cell response.
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Echinococcus granulosus antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell response.
Rachele Riganò,Brigitta Buttari,Elisabetta Profumo,Elena Ortona,Federica Delunardo,Paola Margutti,Vincenzo Mattei,Antonella Teggi,Maurizio Sorice,Alessandra Siracusano +9 more
TL;DR: Results suggest that E. granulosus escapes host immunosurveillance in two ways: by interfering with monocyte differentiation and by modulating DC maturation.
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Native and recombinant antigens in the immunodiagnosis of human cystic echinococcosis
Elena Ortona,Rachele Riganò,Paola Margutti,Sergio Notargiacomo,S. Ioppolo,Sergio Vaccari,Stefano Barca,Brigitta Buttari,Elisabetta Profumo,Antonella Teggi,Alessandra Siracusano +10 more
TL;DR: The findings underline the need to standardize techniques and antigenic preparations and to improve the performance of immunodiagnosis by characterizing new antigens and detecting distinct immunoglobulin classes.