A
Alessandro Ieraci
Researcher at University of Milan
Publications - 39
Citations - 2935
Alessandro Ieraci is an academic researcher from University of Milan. The author has contributed to research in topics: Brain-derived neurotrophic factor & Medicine. The author has an hindex of 16, co-authored 29 publications receiving 2451 citations. Previous affiliations of Alessandro Ieraci include University of Trieste & Cornell University.
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Journal ArticleDOI
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Zhe-Yu Chen,Deqiang Jing,Kevin G. Bath,Alessandro Ieraci,Tanvir Khan,Chia-Jen Siao,Daniel G. Herrera,Miklós Tóth,Chingwen Yang,Bruce S. McEwen,Barbara L. Hempstead,Francis S. Lee +11 more
TL;DR: A variant BDNF mouse (BDNFMet/Met) is generated that reproduces the phenotypic hallmarks in humans with the variant allele and may play a key role in genetic predispositions to anxiety and depressive disorders.
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Sortilin Controls Intracellular Sorting of Brain-Derived Neurotrophic Factor to the Regulated Secretory Pathway
Zhe-Yu Chen,Alessandro Ieraci,Henry Teng,Henning Dall,Chui-Xiang Meng,Daniel G. Herrera,Anders Nykjaer,Barbara L. Hempstead,Francis S. Lee +8 more
TL;DR: A novel function for a Vps10p domain protein, sortilin, in controlling BDNF sorting to the regulated secretory pathway and a framework, based on divergent presynaptic regulation of sorting to secretory pathways, to explain how two ligands for tropomyosin-related kinase B, BDNF and NT-4, can mediate diverse biological responses are explained.
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Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice.
TL;DR: Results suggest that anxious- and depressive-like behavior induced by social isolation stress correlates with reduction of several neuroplasticity-related genes in the hippocampus and prefrontal cortex of adult male mice.
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Nicotinamide Protects against Ethanol-Induced Apoptotic Neurodegeneration in the Developing Mouse Brain
TL;DR: Nicotinamide can prevent some of the deleterious effects of ethanol on the developing mouse brain when given shortly after ethanol exposure, suggesting that nicotinamide, which has been used in humans for the treatment of diabetes and bullous pemphigoid, may hold promise as a preventive therapy of FAS.
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A Novel Endocytic Recycling Signal Distinguishes Biological Responses of Trk Neurotrophin Receptors
TL;DR: The results indicate that TrkA receptors, which predominantly recycle in signal-dependent manner, have unique biological properties dictated by its specific endocytic trafficking itinerary.