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Anders Nykjaer
Researcher at Aarhus University
Publications - 143
Citations - 15367
Anders Nykjaer is an academic researcher from Aarhus University. The author has contributed to research in topics: Receptor & Neurotrophic factors. The author has an hindex of 58, co-authored 139 publications receiving 14169 citations. Previous affiliations of Anders Nykjaer include Aarhus University Hospital & Lundbeck.
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Journal ArticleDOI
An Endocytic Pathway Essential for Renal Uptake and Activation of the Steroid 25-(OH) Vitamin D3
Anders Nykjaer,Duska Dragun,Diego J. Walther,Henrik Vorum,Christian Jacobsen,Joachim Herz,Flemming Melsen,E. I. Christensen,Thomas E. Willnow +8 more
TL;DR: It is demonstrated here that some steroid hormones are taken up by receptor-mediated endocytosis of steroid-carrier complexes, andMegalin-/- mice are unable to retrieve the steroid from the glomerular filtrate and develop vitamin D deficiency and bone disease.
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ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin
Henry K. Teng,Kenneth K. Teng,Ramee Lee,Saundrene Wright,Seema Tevar,Ramiro D. Almeida,Pouneh Kermani,Risa Torkin,Zhe-Yu Chen,Francis S. Lee,Rosemary Kraemer,Anders Nykjaer,Barbara L. Hempstead +12 more
TL;DR: In sympathetic neurons coexpressing sortilin and p75NTR, it is found that proBDNF is an apoptotic ligand that induces death at subnanomolar concentrations, suggesting that the neurotrophin family is capable of modulating diverse biological processes via differential processing of the proneurotrophins.
Journal ArticleDOI
Sortilin is essential for proNGF-induced neuronal cell death
Anders Nykjaer,Ramee Lee,Kenneth K. Teng,Pernille Jansen,Pernille Jansen,Peder Madsen,Morten Nielsen,Christian Jacobsen,Marco Kliemannel,Elisabeth Schwarz,Thomas E. Willnow,Barbara L. Hempstead,Claus Munck Petersen +12 more
TL;DR: It is reported that proNGF creates a signalling complex by simultaneously binding to p 75NTR and sortilin, which acts as a co-receptor and molecular switch governing the p75NTR-mediated pro-apoptotic signal induced by proNGf.
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Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Olav M. Andersen,Juliane Reiche,Vanessa Schmidt,Michael Gotthardt,Robert Spoelgen,Joachim Behlke,Christine A. F. von Arnim,Tilman Breiderhoff,Pernille Jansen,Xin Wu,Kelly R. Bales,Roberto Cappai,Colin L. Masters,Jørgen Gliemann,Elliott J. Mufson,Bradley T. Hyman,Steven M. Paul,Anders Nykjaer,Thomas E. Willnow +18 more
TL;DR: SorLA acts as a sorting receptor that protects APP from processing into Abeta and thereby reduces the burden of amyloidogenic peptide formation and may increase Abeta production and plaque formation and promote spontaneous AD.
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Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.
Anders Nykjaer,Claus Munck Petersen,Bjarne Kuno Møller,Poul Henning Jensen,S K Moestrup,Thor Las Holtet,Michael Etzerodt,Hans Christian Thøgersen,Mette Munch,Peter A. Andreasen +9 more
TL;DR: PAI-1, like uPA and its amino-terminal fragment, bound to the urokinase receptor (uPAR), and the inhibitor-enhanced uPA degradation was blocked by r alpha 2MRAP and inhibited by polyclonal anti-alpha 2MR/LRP antibodies, taken as evidence for mediation of internalization and degradation of uPAR-bound uPA.