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Alessia Baccarini
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 24
Citations - 2528
Alessia Baccarini is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: microRNA & CRISPR. The author has an hindex of 13, co-authored 23 publications receiving 2057 citations.
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Journal ArticleDOI
Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state
Brian D. Brown,Bernhard Gentner,Alessio Cantore,Silvia Colleoni,Mario Amendola,Anna Zingale,Alessia Baccarini,Giovanna Lazzari,Cesare Galli,Luigi Naldini +9 more
TL;DR: These vectors sharply segregated transgene expression between closely related states of therapeutically relevant cells, including dendritic cells, hematopoietic and embryonic stem cells, and their progeny, allowing positive/negative selection according to the cells' differentiation state.
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High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries
Gavriel Mullokandov,Alessia Baccarini,Albert Ruzo,Anitha D. Jayaprakash,Navpreet Tung,Benjamin Israelow,Matthew J. Evans,Ravi Sachidanandam,Brian D. Brown +8 more
TL;DR: A high-throughput assay called Sensor-seq is developed to simultaneously quantify the activity of hundreds of miRNAs, showing that the functional 'miRNome' of a cell is considerably smaller than currently inferred from profiling studies.
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TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation
Priyanka Nair-Gupta,Alessia Baccarini,Navpreet Tung,Fabian Seyffer,Oliver Florey,Yunjie Huang,Meenakshi Banerjee,Michael Overholtzer,Paul A. Roche,Robert Tampé,Brian D. Brown,Derk Amsen,Sidney W. Whiteheart,J. Magarian Blander +13 more
TL;DR: It is shown that MHC-I selectively accumulate within phagosomes carrying microbial components, which engage Toll-like receptor (TLR) signaling and subsequent cross-presentation during infection.
Journal ArticleDOI
Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells
Alessia Baccarini,Hemangini Chauhan,Thomas J. Gardner,Anitha D. Jayaprakash,Ravi Sachidanandam,Brian D. Brown +5 more
TL;DR: In this paper, the authors carried out kinetic analysis of a miRNA's turnover following termination of its biogenesis and during regulation of a target that is not subject to Ago2-mediated catalytic cleavage.
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microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial–mesenchymal transition
Aditya Parikh,Christine Lee,Peronne Joseph,Sergio Marchini,Alessia Baccarini,Valentin Kolev,Chiara Romualdi,Robert Fruscio,Hardik Shah,Feng Wang,Gavriel Mullokandov,David A. Fishman,Maurizio D'Incalci,Jamal Rahaman,Tamara Kalir,Raymond W. Redline,Brian D. Brown,Goutham Narla,Analisa DiFeo +18 more
TL;DR: It is shown that miR-181a promotes TGF-β-mediated epithelial-to-mesenchymal transition via repression of its functional target, Smad7, and its expression is associated with shorter time to recurrence and poor outcome in patients with EOC.