A
Alessia Grozio
Researcher at University of Genoa
Publications - 40
Citations - 2316
Alessia Grozio is an academic researcher from University of Genoa. The author has contributed to research in topics: NAD+ kinase & Nicotinamide mononucleotide. The author has an hindex of 19, co-authored 38 publications receiving 1521 citations. Previous affiliations of Alessia Grozio include National Cancer Research Institute & Washington University in St. Louis.
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Journal ArticleDOI
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.
Kathryn F. Mills,Shohei Yoshida,Liana R. Stein,Alessia Grozio,Shunsuke Kubota,Yo Sasaki,Philip Redpath,Marie E. Migaud,Rajendra S. Apte,Koji Uchida,Jun Yoshino,Shin-ichiro Imai +11 more
TL;DR: NMN suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies and highlighted the preventive and therapeutic potential of NAD+ intermediates as effective anti-aging interventions in humans.
Journal ArticleDOI
NAD+ metabolism and its roles in cellular processes during ageing
Anthony J. Covarrubias,Anthony J. Covarrubias,Rosalba Perrone,Alessia Grozio,Eric Verdin,Eric Verdin +5 more
TL;DR: Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it central to energy metabolism and is also an essential cofactor for non-redox NAD+-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases as discussed by the authors.
Journal ArticleDOI
Slc12a8 is a nicotinamide mononucleotide transporter
Alessia Grozio,Kathryn F. Mills,Jun Yoshino,Santina Bruzzone,Giovanna Sociali,Kyohei Tokizane,Hanyue Cecilia Lei,Richard Cunningham,Yo Sasaki,Marie E. Migaud,Shin-ichiro Imai +10 more
TL;DR: A specific NMN transporter is discovered, encoded by the Slc12a8 gene, which regulates NMN uptake and cellular NAD+ levels in vitro and in the mouse intestine in vivo, and demonstrates that Slc 12a8 has a critical role in regulating intestinal NAD+ metabolism.
Journal ArticleDOI
The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
Inga Bauer,Alessia Grozio,Denise Lasigliè,Giovanna Basile,Laura Sturla,Mirko Magnone,Giovanna Sociali,Debora Soncini,Irene Caffa,Alessandro Poggi,Gabriele Zoppoli,Michele Cea,Michele Cea,Georg Feldmann,Raul Mostoslavsky,Alberto Ballestrero,Franco Patrone,Santina Bruzzone,Alessio Nencioni +18 more
TL;DR: It is shown that SIRT6 enhances the expression of pro-inflammatory cyto-/chemokines, such as IL8 and TNF, and promotes cell migration in pancreatic cancer cells by enhancing Ca2+ responses.
Journal ArticleDOI
CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells
Alessia Grozio,Giovanna Sociali,Laura Sturla,Irene Caffa,Debora Soncini,Annalisa Salis,Nadia Raffaelli,Antonio De Flora,Alessio Nencioni,Santina Bruzzone +9 more
TL;DR: It is demonstrated that low micromolar concentrations of extracellular NAD+ or NAD+ precursors, nicotinamide mononucleotide (NMN) and NR, can reverse the FK866-induced cell death, this representing a plausible explanation for the failure of NAMPT inhibition as an anti-cancer therapy.