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Nadia Raffaelli
Researcher at Marche Polytechnic University
Publications - 105
Citations - 4483
Nadia Raffaelli is an academic researcher from Marche Polytechnic University. The author has contributed to research in topics: NAD+ kinase & Nicotinamide-nucleotide adenylyltransferase. The author has an hindex of 37, co-authored 97 publications receiving 3722 citations. Previous affiliations of Nadia Raffaelli include University of Florida & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
De novo NAD + synthesis enhances mitochondrial function and improves health
Elena Katsyuba,Adrienne Mottis,Marika Zietak,Marika Zietak,Francesca De Franco,Vera van der Velpen,Karim Gariani,Karim Gariani,Dongryeol Ryu,Dongryeol Ryu,Lucia Cialabrini,Olli Matilainen,Olli Matilainen,Paride Liscio,Nicola Giacchè,Nadine Stokar-Regenscheit,Nadine Stokar-Regenscheit,David Legouis,Sophie de Seigneux,Julijana Ivanisevic,Nadia Raffaelli,Kristina Schoonjans,Roberto Pellicciari,Johan Auwerx +23 more
TL;DR: Genetic or pharmacological inhibition of α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase increases NAD+ and improves mitochondrial function in nematodes and mice, and may have therapeutic potential in kidney and liver disease.
Journal ArticleDOI
Enzymology of NAD+ homeostasis in man.
TL;DR: The regulation of NAD+ homeostasis with respect to the physiological role played by the enzymes both utilizing NAD+ through the nonredox NAD+-dependent reactions and catalyzing the recycling of the common product, nicotinamide, is discussed.
Book ChapterDOI
Enzymology of Nad+ Synthesis
TL;DR: This review describes the enzymes involved in pyridine nucleotide metabolism, starting with a detailed consideration of the anaerobic and aerobic pathways leading to quinolinate, a key precursor of NAD+.
Journal ArticleDOI
Molecular Cloning, Chromosomal Localization, Tissue mRNA Levels, Bacterial Expression, and Enzymatic Properties of Human NMN Adenylyltransferase
Monica Emanuelli,Francesco Carnevali,Franca Saccucci,Francesca Pierella,Adolfo Amici,Nadia Raffaelli,Giulio Magni +6 more
TL;DR: The molecular and kinetic properties of recombinant human NMN adenylyltransferase provide new directions for investigating metabolic pathways involving this enzyme.
Journal ArticleDOI
Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.
Valentina Audrito,Sara Serra,Davide Brusa,Francesca Mazzola,Francesca Arruga,Tiziana Vaisitti,Marta Coscia,Rossana Maffei,Davide Rossi,Tao Wang,Giorgio Inghirami,Giorgio Inghirami,Giorgio Inghirami,Menico Rizzi,Gianluca Gaidano,Joe G.N. Garcia,Cynthia Wolberger,Nadia Raffaelli,Silvia Deaglio +18 more
TL;DR: It is shown that both intracellular and extracellular NAMPT levels are increased in cells and plasma of chronic lymphocytic leukemia (CLL) patients, revealing that eNAMPT is a critical element in the induction of an immunosuppressive and tumor-promoting microenvironment of CLL.