Rosalba Perrone

TL;DR: Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it central to energy metabolism and is also an essential cofactor for non-redox NAD+-dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases as discussed by the authors.

TL;DR: It is shown that pro-inflammatory M1-like macrophage, but not naive or M2 macrophages, accumulate in metabolic tissues, including visceral white adipose tissue and liver, during ageing and acute responses to inflammation, and that inflammatory cytokines secreted by senescent cells inducemacrophages to proliferate and express CD38.

TL;DR: Investigation of the presence and conservation of G-quadruplexes in the Retroviridae family indicates new possible pathways in the management of retroviral infections in humans and animal species and sheds light on the mechanism and functions of Retrovirus genomes and derived transposable elements in the human genome.

TL;DR: It is reported that pro-inflammatory M1-like macrophages, but not naïve or M2 macrophage, accumulate in metabolic tissues including visceral white adipose tissue and the liver during aging, highlighting a new causal link between visceral tissue senescence and tissue NAD decline during aging.

TL;DR: A link of FOXO1, ER stress and HIV infection that could be therapeutically exploited to selectively reverse T-cell quiescence and reduce the size of the latent viral reservoir is uncovered.