A
Alessio Delogu
Researcher at King's College London
Publications - 40
Citations - 2278
Alessio Delogu is an academic researcher from King's College London. The author has contributed to research in topics: Neocortex & Thalamus. The author has an hindex of 14, co-authored 33 publications receiving 1957 citations. Previous affiliations of Alessio Delogu include Spanish National Research Council & Research Institute of Molecular Pathology.
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Journal ArticleDOI
Pax5: the guardian of B cell identity and function.
TL;DR: Conditional Pax5 inactivation in early and late B lymphocytes revealed an essential role in controlling the identity and function of B cells throughout B lymphopoiesis, and was implicated in human B cell malignancies.
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Gene Repression by Pax5 in B Cells Is Essential for Blood Cell Homeostasis and Is Reversed in Plasma Cells
Alessio Delogu,Alexandra Schebesta,Qiong Sun,Katharina Aschenbrenner,Thomas Perlot,Meinrad Busslinger +5 more
TL;DR: E ectopic expression of the Pax5-repressed chemokine gene Ccl3 in B cells results in increased osteoclast formation and bone loss, demonstrating that Pax 5-mediated gene repression is essential for normal homeostasis of hematopoietic development.
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Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development
Stephen Malin,Shane McManus,César Cobaleda,César Cobaleda,Maria Novatchkova,Alessio Delogu,Alessio Delogu,Philippe Bouillet,Andreas Strasser,Meinrad Busslinger +9 more
TL;DR: It is demonstrated that the development of pro-B cells was restored by transgenic expression of the prosurvival protein Bcl-2, which compensated for loss of the antiapoptotic protein Mcl-1.
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Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function.
Alexandra Schebesta,Shane McManus,Giorgia Salvagiotto,Alessio Delogu,Georg A. Busslinger,Meinrad Busslinger +5 more
TL;DR: 170 Pax5-activated genes code for key regulatory and structural proteins involved in B cell signaling, adhesion, migration, antigen presentation, and germinal-center B cell formation, thus revealing a complex regulatory network that is activated by Pax5 to control B cell development and function.
Journal ArticleDOI
Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow.
Rosana Pelayo,Jun Hirose,Jun Hirose,Jiaxue Huang,Jiaxue Huang,Karla P. Garrett,Karla P. Garrett,Alessio Delogu,Alessio Delogu,Meinrad Busslinger,Meinrad Busslinger,Paul W. Kincade,Paul W. Kincade +12 more
TL;DR: 2 functionally specialized subsets of pDCs arise in bone marrow from progenitors that diverge from B, T, and NK lineages at an early stage.