César Cobaleda

TL;DR: Conditional Pax5 inactivation in early and late B lymphocytes revealed an essential role in controlling the identity and function of B cells throughout B lymphopoiesis, and was implicated in human B cell malignancies.

TL;DR: It is shown that conditional Pax5 deletion in mice allowed mature B cells from peripheral lymphoid organs to dedifferentiate in vivo back to early uncommitted progenitors in the bone marrow, which rescued T lymphopoiesis in the thymus of T-cell-deficient mice and uncovered an extraordinary plasticity of mature peripheral B cells despite their advanced differentiation stage.

TL;DR: It is demonstrated that the cell capable of initiating human Ph(1)-ALL in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID), termed SCID leukemia-initiating cell (SL-IC), possesses the differentiative and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell.

TL;DR: It is demonstrated that the development of pro-B cells was restored by transgenic expression of the prosurvival protein Bcl-2, which compensated for loss of the antiapoptotic protein Mcl-1.

TL;DR: It is demonstrated by conditional mutagenesis that E2A is essential for the development of pro-B, pre- B, and immature B cells in the bone marrow and dispensable for the generation of mature B cells and plasma cells in peripheral lymphoid organs.