A
Alex F. Bagley
Researcher at Broad Institute
Publications - 1
Citations - 2621
Alex F. Bagley is an academic researcher from Broad Institute. The author has contributed to research in topics: mTORC2 & MLST8. The author has an hindex of 1, co-authored 1 publications receiving 2479 citations. Previous affiliations of Alex F. Bagley include Massachusetts Institute of Technology.
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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D. Sarbassov,Siraj M. Ali,Siraj M. Ali,Shomit Sengupta,Shomit Sengupta,Joon Ho Sheen,Joon Ho Sheen,Peggy P. Hsu,Peggy P. Hsu,Alex F. Bagley,Alex F. Bagley,Andrew L. Markhard,Andrew L. Markhard,David M. Sabatini,David M. Sabatini +14 more
TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.