P
Peggy P. Hsu
Researcher at Harvard University
Publications - 22
Citations - 7865
Peggy P. Hsu is an academic researcher from Harvard University. The author has contributed to research in topics: Biology & Cancer cell. The author has an hindex of 13, co-authored 17 publications receiving 6896 citations. Previous affiliations of Peggy P. Hsu include Broad Institute & Massachusetts Institute of Technology.
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Journal ArticleDOI
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D. Sarbassov,Siraj M. Ali,Siraj M. Ali,Shomit Sengupta,Shomit Sengupta,Joon Ho Sheen,Joon Ho Sheen,Peggy P. Hsu,Peggy P. Hsu,Alex F. Bagley,Alex F. Bagley,Andrew L. Markhard,Andrew L. Markhard,David M. Sabatini,David M. Sabatini +14 more
TL;DR: It is shown that rapamycin inhibits the assembly of mTORC2 and that, in many cell types, prolongedRapamycin treatment reduces the levels of m TORC2 below those needed to maintain Akt/PKB signaling.
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Cancer Cell Metabolism: Warburg and Beyond
TL;DR: The Warburg effect of aerobic glycolysis is re-examine and a framework for understanding its contribution to the altered metabolism of cancer cells is established.
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Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
Richard Possemato,Kevin Marks,Yoav D. Shaul,Michael E. Pacold,Dohoon Kim,Kıvanç Birsoy,Shalini Sethumadhavan,Hin-Koon Woo,Hyun Gyung Jang,Abhishek K. Jha,Walter W. Chen,Francesca G. Barrett,Nicolas Stransky,Zhi-Yang Tsun,Glenn S. Cowley,Jordi Barretina,Jordi Barretina,Nada Y. Kalaany,Peggy P. Hsu,Kathleen Ottina,Albert M. Chan,Bingbing Yuan,Levi A. Garraway,Levi A. Garraway,David E. Root,Mari Mino-Kenudson,Elena F. Brachtel,Edward M. Driggers,David M. Sabatini +28 more
TL;DR: Results reveal that certain breast cancers are dependent upon increased serine pathway flux caused by PHGDH overexpression and demonstrate the utility of in vivo negative-selection RNAi screens for finding potential anticancer targets.
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The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
Peggy P. Hsu,Seong A. Kang,Jonathan Rameseder,Yi Zhang,Kathleen Ottina,Kathleen Ottina,Daniel Lim,Timothy R. Peterson,Yongmun Choi,Nathanael S. Gray,Michael B. Yaffe,Jarrod A. Marto,David M. Sabatini +12 more
TL;DR: It is found that the phosphorylation response to insulin is largely mTOR dependent and that mTOR exhibits a unique preference for proline, hydrophobic, and aromatic residues at the +1 position.
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Tyrosine kinase gene rearrangements in epithelial malignancies
TL;DR: The clinical outcomes with targeted therapies, aetiologic, pathogenic and clinical features that are associated with cancers harbouring oncogenic fusion kinases, including anaplastic lymphoma kinase (ALK), ROS1 and RET are examined.