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Alex Smith

Researcher at Memorial Sloan Kettering Cancer Center

Publications -  17
Citations -  2488

Alex Smith is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Gene & Gene mapping. The author has an hindex of 15, co-authored 17 publications receiving 2413 citations.

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Gene Expression Analysis of Human Prostate Carcinoma during Hormonal Therapy Identifies Androgen-Responsive Genes and Mechanisms of Therapy Resistance

TL;DR: A genome-wide expression analysis of human prostate cancer during androgen ablation therapy to identify genes regulated by androgen and genes differentially expressed after the development of resistance suggested that resistant tumors have increased sensitivity to and endogenous synthesis of androgenic hormones.
Journal Article

Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease.

TL;DR: A strong correlation between high proliferation rates in metastatic cancers and overexpression of genes that participate in cell cycle regulation, DNA replication, and DNA repair and other functional categories of differentially expressed genes included transcriptional regulation, signaling, signal transduction, cell structure, and motility.
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Prospective Randomized Clinical Trial of the Value of Intraperitoneal Drainage After Pancreatic Resection

TL;DR: The data suggest that the presence of drains failed to reduce either the need for interventional radiologic drainage or surgical exploration for intraabdominal sepsis, and closed suction drainage should not be considered mandatory or standard after pancreatic resection.
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Preparation by recombinant human thyrotropin or thyroid hormone withdrawal are comparable for the detection of residual differentiated thyroid carcinoma

TL;DR: A retrospective analysis of a cohort of patients undergoing routine follow-up testing to detect recurrent thyroid carcinoma over a 2-yr period concludes that preparing patients by rhTSH is diagnostically equivalent to preparing them by THW.
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High Incidence of Positive Peritoneal Cytology in Low-Risk Endometrial Cancer Treated by Laparoscopically Assisted Vaginal Hysterectomy

TL;DR: Treatment of low-risk endometrial cancer by LAVH is associated with a significantly higher incidence of positive peritoneal cytology, which may be due to the retrograde dissemination of cancer cells into theperitoneal cavity during uterine manipulation.