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Alexander Krannich
Researcher at Humboldt University of Berlin
Publications - 4
Citations - 915
Alexander Krannich is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Tumor necrosis factor alpha & Lung injury. The author has an hindex of 3, co-authored 4 publications receiving 497 citations.
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Journal ArticleDOI
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.
Robert Lorenz Chua,Soeren Lukassen,Saskia Trump,Bianca P Hennig,Daniel Wendisch,Fabian Pott,Olivia Debnath,Loreen Thürmann,Florian Kurth,Florian Kurth,Maria Theresa Völker,Julia Kazmierski,Bernd Timmermann,Sven Twardziok,Stefan Schneider,Felix Machleidt,Holger Müller-Redetzky,Melanie Maier,Alexander Krannich,Sein Schmidt,Felix Balzer,Johannes Liebig,Jennifer Loske,Norbert Suttorp,Jürgen Eils,Naveed Ishaque,Uwe G. Liebert,Christof von Kalle,Andreas C. Hocke,Martin Witzenrath,Christine Goffinet,Christian Drosten,Sven Laudi,Irina Lehmann,Christian Conrad,Leif E. Sander,Roland Eils,Roland Eils +37 more
TL;DR: The data suggest that pharmacologic inhibition of the CCR1 and/or CCR5 pathways might suppress immune hyperactivation in critical COVID-19, which likely contribute to clinical observations of heightened inflammatory tissue damage, lung injury and respiratory failure.
Journal ArticleDOI
Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).
Florian Kurth,Florian Kurth,Maria Roennefarth,Charlotte Thibeault,Victor M. Corman,Holger Müller-Redetzky,Mirja Mittermaier,Christoph Ruwwe-Glösenkamp,Katrin Moira Heim,Alexander Krannich,Saskia Zvorc,Sein Schmidt,Lucie Kretzler,Chantip Dang-Heine,Matthias Rose,Michael Hummel,Andreas C. Hocke,Ralf H. Hübner,Bastian Opitz,Marcus A. Mall,Jobst Röhmel,Ulf Landmesser,Burkert Pieske,Samuel Knauss,Matthias Endres,Joachim Spranger,Frank P. Mockenhaupt,Frank Tacke,Sascha Treskatsch,Stefan Angermair,Britta Siegmund,Claudia Spies,Steffen Weber-Carstens,Kai-Uwe Eckardt,Dirk Schürmann,Alexander Uhrig,Miriam Stegemann,Thomas Zoller,Christian Drosten,Norbert Suttorp,Martin Witzenrath,Stefan Hippenstiel,Christof von Kalle,Leif E. Sander +43 more
TL;DR: A basic platform for harmonized, scalable data collection, pathophysiological analysis, and deep phenotyping of COVID-19 enables rapid generation of evidence for improved medical care and identification of candidate therapeutic and preventive strategies.
Posted ContentDOI
Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19
Robert Lorenz Chua,Soeren Lukassen,Saskia Trump,Bianca P Hennig,Daniel Wendisch,Fabian Pott,Olivia Debnath,Loreen Thürmann,Florian Kurth,Florian Kurth,Julia Kazmierski,Bernd Timmermann,Sven Twardziok,Stefan Schneider,Felix Machleidt,Holger Müller-Redetzky,Alexander Krannich,Sein Schmidt,Felix Balzer,Johannes Liebig,Jennifer Loske,Jürgen Eils,Naveed Ishaque,Christof von Kalle,Andreas C. Hocke,Martin Witzenrath,Christine Goffinet,Christian Drosten,Sven Laudi,Irina Lehmann,Christian Conrad,Leif-Erik Sander,Roland Eils,Roland Eils +33 more
TL;DR: This study provides novel insights into the pathophysiology of CO VID-19 and suggests an immunomodulatory therapy along the CCL2, CCL3/CCR1 axis as promising option to prevent and treat critical course of COVID-19.