S
Sven Twardziok
Researcher at Humboldt University of Berlin
Publications - 47
Citations - 7755
Sven Twardziok is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Genome & Reference genome. The author has an hindex of 22, co-authored 45 publications receiving 4970 citations. Previous affiliations of Sven Twardziok include Charité.
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Journal ArticleDOI
Shifting the limits in wheat research and breeding using a fully annotated reference genome
Rudi Appels,Rudi Appels,Kellye Eversole,Nils Stein,Nils Stein,Catherine Feuillet,Beat Keller,Jane Rogers,Curtis J. Pozniak,Frédéric Choulet,Assaf Distelfeld,Jesse Poland,Gil Ronen,Andrew G. Sharpe,Omer Barad,Kobi Baruch,Gabriel Keeble-Gagnère,Martin Mascher,Gil Ben-Zvi,Ambre-Aurore Josselin,Axel Himmelbach,François Balfourier,Juan J. Gutierrez-Gonzalez,Matthew J. Hayden,Chushin Koh,Gary J. Muehlbauer,Raj K. Pasam,Etienne Paux,Philippe Rigault,Josquin Tibbits,Vijay K. Tiwari,Manuel Spannagl,Daniel Lang,Heidrun Gundlach,Georg Haberer,Klaus F. X. Mayer,Danara Ormanbekova,Verena M. Prade,Hana Šimková,Thomas Wicker,David Swarbreck,Hélène Rimbert,Marius Felder,Nicolas Guilhot,Gemy Kaithakottil,Jens Keilwagen,Philippe Leroy,Thomas Lux,Sven Twardziok,Luca Venturini,Angéla Juhász,Michael Abrouk,Iris Fischer,Cristobal Uauy,Philippa Borrill,Ricardo H. Ramirez-Gonzalez,Dominique Arnaud,Smahane Chalabi,Boulos Chalhoub,Boulos Chalhoub,Aron T. Cory,Raju Datla,Mark W. Davey,John Jacobs,Stephen J. Robinson,Burkhard Steuernagel,Fred van Ex,Brande B. H. Wulff,Moussa Benhamed,Abdelhafid Bendahmane,Lorenzo Concia,David Latrasse,Jan Bartoš,Arnaud Bellec,Hélène Bergès,Jaroslav Doležel,Zeev Frenkel,Bikram S. Gill,Abraham B. Korol,Thomas Letellier,Odd-Arne Olsen,Kuldeep Singh,Miroslav Valárik,Edwin A. G. van der Vossen,Sonia Vautrin,Song Weining,Tzion Fahima,Vladimir Glikson,Dina Raats,Jarmila Číhalíková,Helena Toegelová,Jan Vrána,Pierre Sourdille,Benoit Darrier,D. Barabaschi,Luigi Cattivelli,Pilar Hernández,Sergio Gálvez,Hikmet Budak,Jonathan D. G. Jones,Kamil Witek,Guotai Yu,Ian Small,Joanna Melonek,Ruonan Zhou,Tatiana Belova,Kostya Kanyuka,Robert King,Kirby T. Nilsen,Sean Walkowiak,Richard D. Cuthbert,Ron Knox,Krysta Wiebe,Daoquan Xiang,Antje Rohde,Timothy Golds,Jana Čížková,Bala Ani Akpinar,Sezgi Biyiklioglu,Liangliang Gao,Amidou N’Daiye,Marie Kubaláková,Jan Šafář,Françoise Alfama,Anne-Françoise Adam-Blondon,Raphael Flores,Claire Guerche,Mikaël Loaec,Hadi Quesneville,Janet A. Condie,Jennifer Ens,Ron MacLachlan,Yifang Tan,Adriana Alberti,Jean-Marc Aury,Valérie Barbe,Arnaud Couloux,Corinne Cruaud,Karine Labadie,Sophie Mangenot,Patrick Wincker,Patrick Wincker,Gaganpreet Kaur,Ming-Cheng Luo,Sunish K. Sehgal,Parveen Chhuneja,O. P. Gupta,Suruchi Jindal,Parampreet Kaur,Palvi Malik,Priti Sharma,Bharat Yadav,Nagendra K. Singh,Jitendra P. Khurana,Chanderkant Chaudhary,Paramjit Khurana,Vinod Kumar,Ajay Kumar Mahato,Saloni Mathur,Amitha Mithra Sevanthi,Naveen Sharma,Ram Sewak Singh Tomar,Kateřina Holušová,Ondřej Plíhal,Matthew D. Clark,Matthew D. Clark,Darren Heavens,George Kettleborough,Jon Wright,Barbora Balcárková,Yuqin Hu,Elena A. Salina,Nikolai V. Ravin,Nikolai V. Ravin,Konstantin G. Skryabin,Konstantin G. Skryabin,Alexey V. Beletsky,Vitaly V. Kadnikov,Andrey V. Mardanov,Michail A. Nesterov,Andrey L. Rakitin,Ekaterina M. Sergeeva,Hirokazu Handa,Hiroyuki Kanamori,Satoshi Katagiri,Fuminori Kobayashi,Shuhei Nasuda,Tsuyoshi Tanaka,Jianzhong Wu,Federica Cattonaro,Min Jiumeng,Karl G. Kugler,Matthias Pfeifer,Simen Rød Sandve,Xu Xun,Bujie Zhan,Jacqueline Batley,Philipp E. Bayer,David Edwards,Satomi Hayashi,Zuzana Tulpová,Paul Visendi,Licao Cui,Xianghong Du,Kewei Feng,Xiaojun Nie,Wei Tong,Le Wang +207 more
TL;DR: This annotated reference sequence of wheat is a resource that can now drive disruptive innovation in wheat improvement, as this community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.
Journal ArticleDOI
A chromosome conformation capture ordered sequence of the barley genome
Martin Mascher,Heidrun Gundlach,Axel Himmelbach,Sebastian Beier,Sven Twardziok,Thomas Wicker,Volodymyr Radchuk,Christoph Dockter,Pete E. Hedley,Joanne Russell,Micha Bayer,Luke Ramsay,Hui Liu,Georg Haberer,Xiao-Qi Zhang,Qisen Zhang,Roberto A. Barrero,Lin Li,Stefan Taudien,Marco Groth,Marius Felder,Alex Hastie,Hana Šimková,Helena Staňková,Jan Vrána,Saki Chan,María Muñoz-Amatriaín,Rachid Ounit,Steve Wanamaker,Dan Bolser,Christian Colmsee,Thomas Schmutzer,Lala Aliyeva-Schnorr,Stefano Grasso,Jaakko Tanskanen,Anna Chailyan,Dharanya Sampath,Darren Heavens,Leah Clissold,Sujie Cao,Brett Chapman,Fei Dai,Yong Han,Hua Li,Xuan Li,Chongyun Lin,John K. McCooke,Cong Tan,Penghao Wang,Songbo Wang,Shuya Yin,Gaofeng Zhou,Jesse Poland,Matthew I. Bellgard,Ljudmilla Borisjuk,Andreas Houben,Jaroslav Doležel,Sarah Ayling,Stefano Lonardi,Paul J. Kersey,Peter Langridge,Gary J. Muehlbauer,Matthew D. Clark,Matthew D. Clark,Mario Caccamo,Mario Caccamo,Alan H. Schulman,Klaus F. X. Mayer,Matthias Platzer,Timothy J. Close,Uwe Scholz,Mats Hansson,Guoping Zhang,Ilka Braumann,Manuel Spannagl,Chengdao Li,Chengdao Li,Chengdao Li,Robbie Waugh,Robbie Waugh,Nils Stein,Nils Stein +81 more
TL;DR: The importance of the barley reference sequence for breeding is demonstrated by inspecting the genomic partitioning of sequence variation in modern elite germplasm, highlighting regions vulnerable to genetic erosion.
Journal ArticleDOI
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.
Robert Lorenz Chua,Soeren Lukassen,Saskia Trump,Bianca P Hennig,Daniel Wendisch,Fabian Pott,Olivia Debnath,Loreen Thürmann,Florian Kurth,Florian Kurth,Maria Theresa Völker,Julia Kazmierski,Bernd Timmermann,Sven Twardziok,Stefan Schneider,Felix Machleidt,Holger Müller-Redetzky,Melanie Maier,Alexander Krannich,Sein Schmidt,Felix Balzer,Johannes Liebig,Jennifer Loske,Norbert Suttorp,Jürgen Eils,Naveed Ishaque,Uwe G. Liebert,Christof von Kalle,Andreas C. Hocke,Martin Witzenrath,Christine Goffinet,Christian Drosten,Sven Laudi,Irina Lehmann,Christian Conrad,Leif E. Sander,Roland Eils,Roland Eils +37 more
TL;DR: The data suggest that pharmacologic inhibition of the CCR1 and/or CCR5 pathways might suppress immune hyperactivation in critical COVID-19, which likely contribute to clinical observations of heightened inflammatory tissue damage, lung injury and respiratory failure.
Journal ArticleDOI
Wild emmer genome architecture and diversity elucidate wheat evolution and domestication
Raz Avni,Moran Nave,Omer Barad,Kobi Baruch,Sven Twardziok,Heidrun Gundlach,Iago Hale,Martin Mascher,Manuel Spannagl,Krystalee Wiebe,Katherine W. Jordan,Guy Golan,Jasline Deek,Batsheva Ben-Zvi,Gil Ben-Zvi,Axel Himmelbach,Ron MacLachlan,Andrew G. Sharpe,Allan K. Fritz,Roi Ben-David,Hikmet Budak,Tzion Fahima,Abraham B. Korol,Justin D. Faris,Alvaro G. Hernandez,Mark A. Mikel,Avraham A. Levy,Brian J. Steffenson,Marco Maccaferri,Roberto Tuberosa,Luigi Cattivelli,Primetta Faccioli,Aldo Ceriotti,Khalil Kashkush,Mohammad Pourkheirandish,Takao Komatsuda,Tamar Eilam,Hanan Sela,Amir Sharon,Nir Ohad,Daniel A. Chamovitz,Klaus F. X. Mayer,Nils Stein,Gil Ronen,Zvi Peleg,Curtis J. Pozniak,Eduard Akhunov,Assaf Distelfeld +47 more
TL;DR: A 10.1-gigabase assembly of the 14 chromosomes of wild tetraploid wheat, as well as analyses of gene content, genome architecture, and genetic diversity reveal genomic regions bearing the signature of selection under domestication.
Journal ArticleDOI
Sustainable data analysis with Snakemake.
Felix Mölder,Kim Philipp Jablonski,Kim Philipp Jablonski,Brice Letcher,Michael B Hall,Christopher Tomkins-Tinch,Christopher Tomkins-Tinch,Vanessa Sochat,Jan Forster,Jan Forster,Soohyun Lee,Sven Twardziok,Alexander Kanitz,Alexander Kanitz,Andreas Wilm,Manuel Holtgrewe,Sven Rahmann,Sven Nahnsen,Johannes Köster,Johannes Köster +19 more
TL;DR: It is shown how the popular workflow management system Snakemake can be used to guarantee reproducibility, and how it enables an ergonomic, combined, unified representation of all steps involved in data analysis, ranging from raw data processing, to quality control and fine-grained, interactive exploration and plotting of final results.