H
Holger Müller-Redetzky
Researcher at Humboldt University of Berlin
Publications - 46
Citations - 2795
Holger Müller-Redetzky is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Lung injury & Lung. The author has an hindex of 15, co-authored 39 publications receiving 1429 citations. Previous affiliations of Holger Müller-Redetzky include Charité.
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Journal ArticleDOI
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment.
Jonas Schulte-Schrepping,Nico Reusch,Daniela Paclik,Kevin Baßler,Stephan Schlickeiser,Bowen Zhang,Benjamin Krämer,Tobias Krammer,Sophia Brumhard,Lorenzo Bonaguro,Elena De Domenico,Daniel Wendisch,Martin Grasshoff,Theodore S. Kapellos,Michael Beckstette,Tal Pecht,Adem Saglam,Oliver Dietrich,Henrik E. Mei,Axel Schulz,Claudia Conrad,Désirée Kunkel,Ehsan Vafadarnejad,Cheng-Jian Xu,Cheng-Jian Xu,Arik Horne,Miriam Herbert,Anna Drews,Charlotte Thibeault,Moritz Pfeiffer,Stefan Hippenstiel,Andreas C. Hocke,Holger Müller-Redetzky,Katrin-Moira Heim,Felix Machleidt,Alexander Uhrig,Laure Bosquillon de Jarcy,Linda Jürgens,Miriam Stegemann,Christoph R. Glösenkamp,Hans-Dieter Volk,Christine Goffinet,Markus Landthaler,Emanuel Wyler,Philipp Georg,Maria Schneider,Chantip Dang-Heine,Nick Neuwinger,Kai Kappert,Rudolf Tauber,Victor M. Corman,Jan Raabe,Kim Melanie Kaiser,Michael To Vinh,Gereon Rieke,Christian Meisel,Thomas Ulas,Matthias Becker,Robert Geffers,Martin Witzenrath,Christian Drosten,Norbert Suttorp,Christof von Kalle,Florian Kurth,Florian Kurth,Florian Kurth,Kristian Händler,Joachim L. Schultze,Joachim L. Schultze,Anna C. Aschenbrenner,Anna C. Aschenbrenner,Yang Li,Yang Li,Jacob Nattermann,Birgit Sawitzki,Antoine-Emmanuel Saliba,Leif E. Sander,Angel Angelov,Robert Bals,Alexander Bartholomäus,Anke Becker,Daniela Bezdan,Ezio Bonifacio,Peer Bork,Thomas Clavel,Maria Colomé-Tatché,Andreas Diefenbach,Alexander T. Dilthey,Nicole Fischer,Konrad U. Förstner,Julia-Stefanie Frick,Julien Gagneur,Alexander Goesmann,Torsten Hain,Michael Hummel,Stefan Janssen,Jörn Kalinowski,René Kallies,Birte Kehr,Andreas Keller,Sarah Kim-Hellmuth,Christoph Klein,Oliver Kohlbacher,Jan O. Korbel,Ingo Kurth,Kerstin U. Ludwig,Oliwia Makarewicz,Manja Marz,Alice C. McHardy,Christian Mertes,Markus M. Nöthen,Peter Nürnberg,Uwe Ohler,Stephan Ossowski,Jörg Overmann,Silke Peter,Klaus Pfeffer,Anna R. Poetsch,Alfred Pühler,Nikolaus Rajewsky,Markus Ralser,Olaf Rieß,Stephan Ripke,Ulisses Nunes da Rocha,Philip Rosenstiel,Philipp H. Schiffer,Eva-Christina Schulte,Alexander Sczyrba,Oliver Stegle,Jens Stoye,Fabian J. Theis,Janne Vehreschild,Jörg Vogel,Max von Kleist,Andreas Walker,Jörn Walter,Dagmar Wieczorek,John Ziebuhr +137 more
TL;DR: This study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.
Journal ArticleDOI
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.
Robert Lorenz Chua,Soeren Lukassen,Saskia Trump,Bianca P Hennig,Daniel Wendisch,Fabian Pott,Olivia Debnath,Loreen Thürmann,Florian Kurth,Florian Kurth,Maria Theresa Völker,Julia Kazmierski,Bernd Timmermann,Sven Twardziok,Stefan Schneider,Felix Machleidt,Holger Müller-Redetzky,Melanie Maier,Alexander Krannich,Sein Schmidt,Felix Balzer,Johannes Liebig,Jennifer Loske,Norbert Suttorp,Jürgen Eils,Naveed Ishaque,Uwe G. Liebert,Christof von Kalle,Andreas C. Hocke,Martin Witzenrath,Christine Goffinet,Christian Drosten,Sven Laudi,Irina Lehmann,Christian Conrad,Leif E. Sander,Roland Eils,Roland Eils +37 more
TL;DR: The data suggest that pharmacologic inhibition of the CCR1 and/or CCR5 pathways might suppress immune hyperactivation in critical COVID-19, which likely contribute to clinical observations of heightened inflammatory tissue damage, lung injury and respiratory failure.
Journal ArticleDOI
A time-resolved proteomic and prognostic map of COVID-19.
Vadim Demichev,Vadim Demichev,Vadim Demichev,Pinkus Tober-Lau,Oliver Lemke,Tatiana Nazarenko,Charlotte Thibeault,Harry J. Whitwell,Annika Röhl,Anja Freiwald,Lukasz Szyrwiel,Daniela Ludwig,Clara Correia-Melo,Simran Kaur Aulakh,Elisa T Helbig,Paula Stubbemann,Lena J Lippert,Nana-Maria Grüning,Oleg Blyuss,Spyros I. Vernardis,Matthew White,Christoph B. Messner,Michael Joannidis,Thomas Sonnweber,Sebastian J. Klein,Alex Pizzini,Yvonne Wohlfarter,Sabina Sahanic,Richard Hilbe,Benedikt Schaefer,Sonja Wagner,Mirja Mittermaier,Felix Machleidt,Carmen Garcia,Christoph Ruwwe-Glösenkamp,Tilman Lingscheid,Laure Bosquillon de Jarcy,Miriam Stegemann,Moritz Pfeiffer,Linda Jürgens,Sophy Denker,Daniel Zickler,Philipp Enghard,Aleksej Zelezniak,Archie Campbell,Caroline Hayward,David J. Porteous,Riccardo E. Marioni,Alexander Uhrig,Holger Müller-Redetzky,Heinz Zoller,Judith Löffler-Ragg +51 more
TL;DR: In this paper, the authors characterized the time-dependent progression of the disease in 139 COVID-19 inpatients by measuring 86 accredited diagnostic parameters, such as blood cell counts and enzyme activities, as well as untargeted plasma proteomes at 687 sampling points.
Journal ArticleDOI
Complement activation induces excessive T cell cytotoxicity in severe COVID-19
Philipp Georg,Rosario Astaburuaga-García,Rosario Astaburuaga-García,Lorenzo Bonaguro,Sophia Brumhard,Laura Michalick,Lena J Lippert,Tomislav Kostevc,Christiane Gäbel,Maria Schneider,Mathias Streitz,Vadim Demichev,Vadim Demichev,Vadim Demichev,Ioanna Gemünd,Ioanna Gemünd,Matthias Barone,Pinkus Tober-Lau,Elisa T Helbig,Julia Stein,Hannah-Philine Dey,Daniela Paclik,Michael Mülleder,Michael Mülleder,Simran Kaur Aulakh,Henrik E. Mei,Axel Schulz,Stefan Hippenstiel,Victor M. Corman,Dieter Beule,Emanuel Wyler,Markus Landthaler,Markus Landthaler,Benedikt Obermayer-Wasserscheid,Peter Boor,Münevve Demir,Hans Wesselmann,Norbert Suttorp,Alexander Uhrig,Holger Müller-Redetzky,Jacob Nattermann,Wolfgang M. Kuebler,Christian Meisel,Markus Ralser,Markus Ralser,Joachim L. Schultze,Anna C. Aschenbrenner,Charlotte Thibeault,Florian Kurth,Florian Kurth,Leif-Erik Sander,Nils Blüthgen,Nils Blüthgen,Birgit Sawitzki +53 more
TL;DR: The proportion of activated CD16+ T cells and plasma levels of complement proteins upstream of C3a correlated with clinical outcome, supporting a pathological role of exacerbated cytotoxicity and complement activation in COVID-19.
Journal ArticleDOI
Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).
Florian Kurth,Florian Kurth,Maria Roennefarth,Charlotte Thibeault,Victor M. Corman,Holger Müller-Redetzky,Mirja Mittermaier,Christoph Ruwwe-Glösenkamp,Katrin Moira Heim,Alexander Krannich,Saskia Zvorc,Sein Schmidt,Lucie Kretzler,Chantip Dang-Heine,Matthias Rose,Michael Hummel,Andreas C. Hocke,Ralf H. Hübner,Bastian Opitz,Marcus A. Mall,Jobst Röhmel,Ulf Landmesser,Burkert Pieske,Samuel Knauss,Matthias Endres,Joachim Spranger,Frank P. Mockenhaupt,Frank Tacke,Sascha Treskatsch,Stefan Angermair,Britta Siegmund,Claudia Spies,Steffen Weber-Carstens,Kai-Uwe Eckardt,Dirk Schürmann,Alexander Uhrig,Miriam Stegemann,Thomas Zoller,Christian Drosten,Norbert Suttorp,Martin Witzenrath,Stefan Hippenstiel,Christof von Kalle,Leif E. Sander +43 more
TL;DR: A basic platform for harmonized, scalable data collection, pathophysiological analysis, and deep phenotyping of COVID-19 enables rapid generation of evidence for improved medical care and identification of candidate therapeutic and preventive strategies.