Journal ArticleDOI
Molecular structure of a left-handed double helical DNA fragment at atomic resolution
Andrew H.-J. Wang,Gary J. Quigley,F. Kolpak,J.L. Crawford,J. H. Van Boom,G. A. Van Der Marel,Alexander Rich +6 more
TLDR
The DNA fragment d(CpGpCpC pGp CpG pG) crystallises as a left-handed double helical molecule with Watson–Crick base pairs and an antiparallel organisation of the sugar phosphate chains.Abstract:
The DNA fragment d(CpGpCpGpCpG) crystallises as a left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains. The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn. It differs significantly from right-handed B-DNA.read more
Citations
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3DNA: a software package for the analysis, rebuilding and visualization of three‐dimensional nucleic acid structures
Xiang-Jun Lu,Wilma K. Olson +1 more
TL;DR: A comprehensive software package for the analysis, reconstruction and visualization of three-dimensional nucleic acid structures that can handle antiparallel and parallel double helices, single-stranded structures, triplexes, quadruplexes and other complex tertiary folding motifs found in both DNA and RNA structures is presented.
Journal ArticleDOI
Circular dichroism and conformational polymorphism of DNA
TL;DR: Here the authors review studies that provided important information about conformational properties of DNA using circular dichroic (CD) spectroscopy, which significantly participated in all basic conformational findings on DNA.
Journal ArticleDOI
Human serum albumin: from bench to bedside.
TL;DR: HSA is a valuable biomarker of many diseases, including cancer, rheumatoid arthritis, ischemia, post-menopausal obesity, severe acute graft-versus-host disease, and diseases that need monitoring of the glycemic control.
Journal ArticleDOI
Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions
TL;DR: The recent advances in supramolecular helical assemblies formed from chiral and achiral small molecules, oligomers (foldamers), and helical and nonhelical polymers from the viewpoints of their formations with unique chiral phenomena, such as amplification of chirality during the dynamic helically assembled processes, properties, and specific functionalities.
References
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Journal ArticleDOI
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
James D. Watson,Francis Crick +1 more
TL;DR: The determination in 1953 of the structure of deoxyribonucleic acid (DNA), with its two entwined helices and paired organic bases, was a tour de force in X-ray crystallography and opened the way for a deeper understanding of perhaps the most important biological process.
Journal ArticleDOI
Salt-induced co-operative conformational change of a synthetic DNA: Equilibrium and kinetic studies with poly(dG-dC)☆
Fritz M. Pohl,Thomas M. Jovin +1 more
TL;DR: The experiments show that an isomerization of DNA with a certain base sequence is possible in solution and the proposed model suggests a plausible mechanism.
Journal ArticleDOI
The treatment of errors in the isomorphous replacement method
D. M. Blow,Francis Crick +1 more
Journal ArticleDOI
Structural Domains of Transfer RNA Molecules
Gary J. Quigley,Alexander Rich +1 more
TL;DR: Various detailed features of the conformation of yeast tRNA(Phe) revealed by recent refinement analysis of x-ray diffraction data at 2.5 A resolution are described.
Journal ArticleDOI
A crystallographic study of metal-binding to yeast phenylalanine transfer RNA.
TL;DR: Different Fourier maps have revealed one major binding site for each of cobalt and managanese in the presence of magnesium, which is probably involved in the first stage of melting of the tRNA molecule, and may be critical for stabilizing the tertiary structure.
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Salt-induced co-operative conformational change of a synthetic DNA: Equilibrium and kinetic studies with poly(dG-dC)☆
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