Benjamin Gaston

TL;DR: Five distinct clinical phenotypes of asthma have been identified using an unsupervised hierarchical cluster analysis, which supports clinical heterogeneity in asthma and the need for new approaches for the classification of disease severity in asthma.

TL;DR: S-nitrosothiols (RS-NO), predominantly the adduct with glutathione, are present at nano- to micromolar concentrations in the airways of normal subjects and that their levels vary in different human pathophysiologic states, suggesting an important role for NO.

TL;DR: It is shown both in vitro and in vivo that nitrosative stress leads to S-nitrosylation of wild-type parkin and, initially, to a dramatic increase followed by a decrease in the E3 ligase-ubiquitin-proteasome degradative pathway, which may provide a molecular link between free radical toxicity and protein accumulation in sporadic Parkinson's disease.

TL;DR: How children with severe asthma are distributed across a cluster analysis and how well these clusters conform to current definitions of asthma severity are determined.

TL;DR: The majority of mitochondrial, but not cytoplasmic, caspase-3 zymogens contain this inhibitory modification S-nitrosylated and these studies suggest that S-Nitrosylation plays an important role in regulating mitochondrial caspases function and that the S- nitrogenous state of a given protein depends on its subcellular localization.