Differentiating connexin hemichannels and pannexin channels in cellular ATP release
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TLDR
Differentiating the distinct signaling pathways that regulate these two channels will advance the current knowledge of cellular communication and aid in the development of novel rationally‐designed drugs for modulation of Panx and Cx activity, respectively.About:
This article is published in FEBS Letters.The article was published on 2014-04-17 and is currently open access. It has received 159 citations till now. The article focuses on the topics: Pannexin & Purinergic signalling.read more
Citations
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Journal ArticleDOI
Physiology of astroglia
TL;DR: Astrocytes are tightly integrated into neural networks and act within the context of neural tissue; astrocytes control homeostasis of the CNS at all levels of organization from molecular to the whole organ.
Journal ArticleDOI
Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications
Luc Leybaert,Paul D. Lampe,Stefan Dhein,Brenda R. Kwak,Péter Ferdinandy,Eric C. Beyer,Dale W. Laird,Christian C. Naus,Colin R. Green,Rainer Schulz +9 more
TL;DR: It is concluded that peptide-based investigations have raised several new opportunities for interfering with connexins and their channels that may soon allow preservation of gap junction communication, inhibition of hemichannel opening, and mitigation of inflammatory signaling.
Journal ArticleDOI
Mechanisms of ATP Release by Inflammatory Cells
TL;DR: Key effector functions of inflammatory cells are regulated by purinergic signaling in acute and chronic diseases, making extracellular nucleotide release a promising target for the development of new therapies.
Journal ArticleDOI
Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation.
Alexander W. Lohman,Igor L. Leskov,Joshua T. Butcher,Scott R. Johnstone,Tara A. Stokes,Daniela Begandt,Leon J. DeLalio,Angela K. Best,Silvia Penuela,Norbert Leitinger,Kodi S. Ravichandran,Karen Y. Stokes,Brant E. Isakson +12 more
TL;DR: It is reported that the ATP-release channel Pannexin1 (Panx1) opens downstream of EC activation by TNF-α, placing Panx1 channels at the centre of cytokine crosstalk with purinergic signalling in the endothelium.
Journal ArticleDOI
Extracellular nucleotides and nucleosides as signalling molecules.
TL;DR: These processes confer a remarkable level of selectivity and plasticity to purinergic signalling that makes this network one of the most relevant extracellular messenger systems in higher organisms.
References
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Book ChapterDOI
Receptors for Purines and Pyrimidines
Vera Ralevic,Geoffrey Burnstock +1 more
TL;DR: In this review particular emphasis is placed on the discrepancy between the concentrations ofadenosine, ADP, and ATP in the purine receptors of UDP and UTP.
Journal ArticleDOI
Activation and regulation of the inflammasomes
TL;DR: The complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response are discussed, and the similarities to another molecular signalling platform — the apoptosome — that monitors cellular health are highlighted.
Journal ArticleDOI
Physiology and Pathophysiology of Purinergic Neurotransmission
TL;DR: This review is focused on purinergic neurotransmission, i.e., ATP released from nerves as a transmitter or cotransmitter to act as an extracellular signaling molecule on both pre- and postjunctional membranes at neuroeffector junctions and synapses, as well as acting as a trophic factor during development and regeneration.
Journal ArticleDOI
Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor
TL;DR: Pannexin‐1, a recently described mammalian protein that functions as a hemichannel when ectopically expressed, is identified as this dye‐uptake pathway and signalling through pannexin•1 is required for processing of caspase‐1 and release of mature IL‐1β induced by P2X7 receptor activation.
Journal ArticleDOI
Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade.
TL;DR: Recent advances in nucleotide-releasing and purine-converting pathways in the vasculature are summarized, with particular emphasis on the nucleotidases of ecto-nucleoside triphosphate diphosphatase/phosphodiesterase family.
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Faraaz B. Chekeni,Michael R. Elliott,Michael R. Elliott,Joanna K. Sandilos,Scott F. Walk,Scott F. Walk,Jason M. Kinchen,Jason M. Kinchen,Eduardo R. Lazarowski,Allison Armstrong,Allison Armstrong,Silvia Penuela,Dale W. Laird,Guy S. Salvesen,Brant E. Isakson,Douglas A. Bayliss,Kodi S. Ravichandran,Kodi S. Ravichandran +17 more