Alexandra S. Bause

TL;DR: Inhibition of autophagy by genetic means or chloroquine treatment leads to robust tumor regression and prolonged survival in pancreatic cancer xenografts and genetic mouse models, and drugs that inactivate this process may have a unique clinical utility in treating pancreatic cancers and other malignancies with a similar dependence on Autophagy.

TL;DR: The mitochondrial sirtuin, SIRT3, is emerging as a pivotal regulator of oxidative stress by deacetylation of substrates involved in both ROS production and detoxification.

TL;DR: It is demonstrated that the cinnamon-derived dietary Michael acceptor trans-cinnamic aldehyde (CA) impairs melanoma cell proliferation and tumor growth and supports a previously unrecognized role of CA as a dietary Michael acceptanceor with potential anti-cancer activity.

TL;DR: Data demonstrate that the cinnamon-derived food factor CA is a potent activator of the Nrf2-orchestrated antioxidant response in cultured human epithelial colon cells, suggesting that CA may represent an underappreciated chemopreventive dietary factor targeting colorectal carcinogenesis.

TL;DR: The results suggest that therapeutic targeting of HDAC6 and/or SIRT2 may represent a new way to treat cancers expressing mutant forms of K-RAS and suggest that altering K- RAS acetylation is a feasible approach to limiting tumorigenic potential.