Georg T. Wondrak

TL;DR: It is reported that inhibition of NF-E2-related factor 2 (Nrf2) may be a promising strategy to combat chemoresistance, and evidence is provided that the strategy of using Nrf2 inhibitors to increase efficacy of chemotherapeutic agents is not limited to certain cancer types or anticancer drugs and thus can be applied during the course of chemotherapy to treat many cancer types.

TL;DR: Experimental evidence is provided indicating that dietary compounds targeting Nrf2 activation can be used therapeutically to improve metabolic disorder and relieve renal damage induced by diabetes.

TL;DR: An update on drug discovery, target identification, and mechanisms of action of experimental redox chemotherapeutics with a focus on pro- and antioxidant redox modulators now in advanced phases of preclinal and clinical development is presented.

TL;DR: Sensitized skin cell photodamage by this bystander mechanism occurs after photoexcitation of sensitizers contained in skin structural proteins without direct cellular photon absorption thereby enhancing the potency and range of phototoxic UVA action in deeper layers of skin.

TL;DR: It is demonstrated that the cinnamon-derived dietary Michael acceptor trans-cinnamic aldehyde (CA) impairs melanoma cell proliferation and tumor growth and supports a previously unrecognized role of CA as a dietary Michael acceptanceor with potential anti-cancer activity.