A
Alexandre Caron
Researcher at University of Texas Southwestern Medical Center
Publications - 47
Citations - 1932
Alexandre Caron is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Leptin & Brown adipose tissue. The author has an hindex of 19, co-authored 36 publications receiving 1410 citations. Previous affiliations of Alexandre Caron include Université du Québec à Montréal & Laval University.
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The Roles of mTOR Complexes in Lipid Metabolism
TL;DR: The roles of mTOR complexes in various aspects of lipid metabolism in mammals are reviewed and the implication of these relations to the maintenance of systemic lipid homeostasis is discussed.
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In vivo measurement of energy substrate contribution to cold-induced brown adipose tissue thermogenesis
Sébastien M. Labbé,Alexandre Caron,Inan Bakan,Mathieu Laplante,André C. Carpentier,Roger Lecomte,Denis Richard +6 more
TL;DR: The cold‐induced increase in oxidative activity was meaningfully blunted by nicotinic acid, a lipolysis inhibitor, which emphasizes in vivo the key role of intracellular lipid in BAT thermogenesis.
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Leptin and brain–adipose crosstalks
TL;DR: A review of anatomical, genetic and pharmacological studies on the neural regulation of adipose function, including lipolysis, non-shivering thermogenesis, browning and leptin secretion, can be found in this article.
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Partial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy.
Shangang Zhao,Yi Zhu,Robbie D. Schultz,Na Li,Zhenyan He,Zhuzhen Zhang,Alexandre Caron,Qingzhang Zhu,Kai Sun,Wei Xiong,Hui Deng,Jia Sun,Jia Sun,Yingfeng Deng,Min Kim,Charlotte E. Lee,Ruth Gordillo,Tiemin Liu,Angela K. Odle,Gwen V. Childs,Ningyan Zhang,Christine M. Kusminski,Joel K. Elmquist,Kevin W. Williams,Zhiqiang An,Philipp E. Scherer +25 more
TL;DR: It is demonstrated that hyperleptinemia is a driving force for metabolic disorders and a partial reduction of plasma leptin levels in the context of obesity restores hypothalamic leptin sensitivity and effectively reduces weight gain and enhances insulin sensitivity.
Journal ArticleDOI
A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.
Aditi Sood,Danny V. Jeyaraju,Julien Prudent,Alexandre Caron,Philippe Lemieux,Heidi M. McBride,Mathieu Laplante,Katalin Tóth,Luca Pellegrini +8 more
TL;DR: In vivo, mitochondria adapt to metabolic shifts through the parallel remodeling of the cristae and of the MERCs via a mechanism that degrades Opa1 in an Mfn2-dependent pathway, which was previously thought to operate independently of each other.