R
Ruth Gordillo
Researcher at University of Texas Southwestern Medical Center
Publications - 73
Citations - 3882
Ruth Gordillo is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Adipose tissue & Adipocyte. The author has an hindex of 25, co-authored 67 publications receiving 2851 citations. Previous affiliations of Ruth Gordillo include University of Extremadura & University of California, Los Angeles.
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Journal ArticleDOI
An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
William L. Holland,Andrew C. Adams,Joseph T. Brozinick,Hai H. Bui,Yukiko Miyauchi,Christine M. Kusminski,Steven M. Bauer,Mark R. Wade,Esha Singhal,Christine C. Cheng,Katherine Volk,Ming Shang Kuo,Ruth Gordillo,Alexei Kharitonenkov,Philipp E. Scherer +14 more
TL;DR: It is shown that FGF21 rapidly and robustly stimulates adiponectin secretion in rodents while diminishing accumulation of ceramides in obese animals, and that F GF21 critically depends on adip onectin to exert its glycemic and insulin sensitizing effects.
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Theory of asymmetric organocatalysis of Aldol and related reactions: rationalizations and predictions.
Christophe Allemann,Ruth Gordillo,Fernando R. Clemente,Paul Ha-Yeon Cheong,Kendall N. Houk,Kendall N. Houk +5 more
TL;DR: Computational studies have led to models to understand some classic and contemporary asymmetric reactions involving organocatalysts, and Quantitative predictions for several new catalysts and reactions are provided.
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Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis
Jonathan Y. Xia,William L. Holland,Christine M. Kusminski,Kai Sun,Ankit X. Sharma,Mackenzie J. Pearson,Angelica J. Sifuentes,Jeffrey G. McDonald,Ruth Gordillo,Philipp E. Scherer +9 more
TL;DR: Observations suggest the existence of a rapidly acting "cross-talk" between liver and adipose tissue sphingolipids, critically regulating glucose metabolism and hepatic lipid uptake.
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An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State
Clair Crewe,Nolwenn Joffin,Joseph M. Rutkowski,Min Kim,Fang Zhang,Dwight A. Towler,Ruth Gordillo,Philipp E. Scherer +7 more
TL;DR: It is shown that neighboring endothelial cells (ECs) transfer cav1-containing EVs to adipocytes in vivo, which reciprocate by releasing EVs to ECs, which facilitates transfer of plasma constituents from ECs to the adipocyte.
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Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis.
Maria Apostolopoulou,Ruth Gordillo,Chrysi Koliaki,Sofia Gancheva,Tomas Jelenik,Elisabetta De Filippo,Christian Herder,Daniel F. Markgraf,Frank Jankowiak,Irene Esposito,Matthias Schlensak,Philipp E. Scherer,Michael Roden +12 more
TL;DR: Sphingolipid species are not only increased in insulin-resistant humans with NASH but also correlate with hepatic oxidative stress and inflammation, suggesting that these lipids may play a role during progression of simple steatosis to NASH in humans.