L
Laurent Gautron
Researcher at University of Texas Southwestern Medical Center
Publications - 82
Citations - 5945
Laurent Gautron is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Hypothalamus & Leptin. The author has an hindex of 32, co-authored 74 publications receiving 5063 citations. Previous affiliations of Laurent Gautron include University of Bordeaux & University of Texas at Dallas.
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Journal ArticleDOI
Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21
Takeshi Inagaki,Paul A. Dutchak,Guixiang Zhao,Xunshan Ding,Laurent Gautron,Vinay Parameswara,Yong Li,Regina Goetz,Moosa Mohammadi,Victoria Esser,Joel K. Elmquist,Robert D. Gerard,Shawn C. Burgess,Robert E. Hammer,David J. Mangelsdorf,Steven A. Kliewer +15 more
TL;DR: These findings demonstrate an unexpected role for the PPARalpha-FGF21 endocrine signaling pathway in regulating diverse metabolic and behavioral aspects of the adaptive response to starvation.
Journal ArticleDOI
FGF21 regulates metabolism and circadian behavior by acting on the nervous system.
Angie L. Bookout,Marleen H.M. de Groot,Bryn M. Owen,Syann Lee,Laurent Gautron,Heather L Lawrence,Xunshan Ding,Joel K. Elmquist,Joseph S. Takahashi,David J. Mangelsdorf,Steven A. Kliewer +10 more
TL;DR: A crucial role for the nervous system is demonstrated in mediating the diverse physiologic and pharmacologic actions of FGF21, which increases systemic glucocorticoid levels, suppresses physical activity and alters circadian behavior, which are all features of the adaptive starvation response.
Journal ArticleDOI
Sixteen years and counting: an update on leptin in energy balance
Laurent Gautron,Joel K. Elmquist +1 more
TL;DR: An update on the most current understanding of leptin-sensitive neural pathways in terms of both anatomical organization and physiological roles is provided.
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A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13
Chad E. Grueter,Eva van Rooij,Brett A. Johnson,Susan M. DeLeon,Lillian B. Sutherland,Xiaoxia Qi,Laurent Gautron,Joel K. Elmquist,Rhonda Bassel-Duby,Eric N. Olson +9 more
TL;DR: A role of the heart in systemic metabolic control is revealed and points to MED13 and miR-208a as potential therapeutic targets for metabolic disorders are pointed to.
Journal ArticleDOI
Characterization of Kiss1 neurons using transgenic mouse models
Roberta M. Cravo,Lisandra O. Margatho,Lisandra O. Margatho,Sherri Osborne-Lawrence,Jose Donato,Stan D. Atkin,Angie L. Bookout,Sherry A. Rovinsky,Renata Frazão,Charlotte E. Lee,Laurent Gautron,Jeffrey M. Zigman,Carol F. Elias +12 more
TL;DR: The differences observed between the Kiss1 neurons in the preoptic area and the Arc likely represent neuronal evidence for their differential roles in metabolism and reproduction.