C
Christine M. Kusminski
Researcher at University of Texas Southwestern Medical Center
Publications - 57
Citations - 8045
Christine M. Kusminski is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Adipose tissue & White adipose tissue. The author has an hindex of 29, co-authored 54 publications receiving 6460 citations. Previous affiliations of Christine M. Kusminski include University of Warwick & Coventry Health Care.
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Journal ArticleDOI
Adipose tissue remodeling and obesity
TL;DR: There are remarkable similarities between adipose expansion and growth of solid tumors, a phenomenon that presents both an opportunity and a challenge, since pharmacological interventions supporting healthy adipose tissue adaptation can also facilitate tumor growth.
Journal ArticleDOI
Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes
S. J. Creely,S. J. Creely,Philip G. McTernan,Christine M. Kusminski,Ff M. Fisher,N. F. da Silva,M. Khanolkar,Marc Evans,Alison L. Harte,Sudhesh Kumar,Sudhesh Kumar +10 more
TL;DR: T2DM is associated with increased endotoxemia, with AT able to initiate an innate immune response, and increased adiposity may increase proinflammatory cytokines and therefore contribute to the pathogenic risk of T2DM.
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Targeting adipose tissue in the treatment of obesity-associated diabetes
TL;DR: An overview of the role of adipose tissue in metabolic homeostasis is provided and emerging novel therapeutic strategies targeting adipOSE tissue are assessed, including adipokine-based strategies, promotion of white adiposa tissue beiging as well as reduction of inflammation and fibrosis.
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An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
William L. Holland,Andrew C. Adams,Joseph T. Brozinick,Hai H. Bui,Yukiko Miyauchi,Christine M. Kusminski,Steven M. Bauer,Mark R. Wade,Esha Singhal,Christine C. Cheng,Katherine Volk,Ming Shang Kuo,Ruth Gordillo,Alexei Kharitonenkov,Philipp E. Scherer +14 more
TL;DR: It is shown that FGF21 rapidly and robustly stimulates adiponectin secretion in rodents while diminishing accumulation of ceramides in obese animals, and that F GF21 critically depends on adip onectin to exert its glycemic and insulin sensitizing effects.
Journal ArticleDOI
MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.
Christine M. Kusminski,William L. Holland,Kai Sun,Jiyoung Park,Stephen B. Spurgin,Ying Lin,G Roger Askew,Judith Simcox,Donald A. McClain,Cai Li,Philipp E. Scherer +10 more
TL;DR: It is found that overexpression of mitoNEET enhances lipid uptake and storage, leading to an expansion of the mass of adipose tissue, causing less weight gain on a high-fat diet.