Tiemin Liu

TL;DR: It is shown that mice deficient in hepatocyte Tlr4 (Tlr4LKO) exhibit improved glucose tolerance, enhanced insulin sensitivity, and ameliorated hepatic steatosis despite the development of obesity after a high fat diet (HFD) challenge, and it is suggested that targeting hepatocytes Tlr 4 might be a useful therapeutic strategy for the treatment of type 2 diabetes.

TL;DR: In this article, the role of excitatory glutamatergic input in controlling AgRP neurons was investigated and it was shown that deletion of NMDARs from AgRP neuron markedly reduced weight, body fat and food intake whereas deletion from POMC neuron had no effect.

TL;DR: Interferon regulatory factor 4 is identified as a dominant transcriptional effector of thermogenesis and induced by cold and cAMP in adipocytes and is sufficient to promote increased thermogenic gene expression, energy expenditure, and cold tolerance.

TL;DR: AgRP neuron-selective GHSR re-expression partially restored the orexigenic response to administered ghrelin and fully restored the lowered blood glucose levels observed upon caloric restriction, indicating that AgRP-containing AgRP neurons are sufficient to mediate gh Relin's effects on glycemia.

TL;DR: In this paper, the unfolded protein response transcription factor spliced X-box binding protein 1 (XBP1s) was shown to protect against diet-induced obesity as well as improve leptin and insulin sensitivity.