Alexandre Gironell

TL;DR: This first multicentre study assessing the long-term efficacy of either STN or GPi stimulation shows a significant and substantial clinically important therapeutic benefit for at least 3-4 years in a large cohort of patients with severe Parkinson's disease.

TL;DR: Performance on the Parkinson's Disease‐Cognitive Rating Scale showed that PDD is characterized by the addition of cortical dysfunction upon a predominant and progressive fronto‐subcortical impairment.

TL;DR: Three patients with PD developed manic behavior after bilateral implantation of electrodes for deep-brain stimulation (DBS) common to all three patients were manic symptoms unremitting after levodopa reduction or stimulation "off," lower electrodes positioning caudal to the subthalamic nucleus area, and resolution of the manic episodes coinciding with stimulation through higher contacts.

TL;DR: DBS fully remitted 50% of the patients at 1 yr, supporting its validity as a new therapeutic strategy for TRD, and all HAMD subscales without a significant incidence of side-effects.

TL;DR: A cross-sectional study of the profile of psychiatric symptoms and their relationships to medications, executive performance, and excessive daytime somnolence (EDS) was conducted on 1351 consecutive Parkinson's disease patients without dementia (PD-ND) as mentioned in this paper.