S
Stig Rehncrona
Researcher at Lund University
Publications - 73
Citations - 11588
Stig Rehncrona is an academic researcher from Lund University. The author has contributed to research in topics: Deep brain stimulation & Parkinson's disease. The author has an hindex of 43, co-authored 73 publications receiving 10985 citations. Previous affiliations of Stig Rehncrona include Czechoslovak Academy of Sciences.
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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
Jia-Yi Li,Elisabet Englund,Janice L. Holton,Denis Soulet,Peter Hagell,Andrew J. Lees,Tammaryn Lashley,Niall Quinn,Stig Rehncrona,Anders Björklund,Håkan Widner,Tamas Revesz,Olle Lindvall,Patrik Brundin +13 more
TL;DR: Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11–16 years) developed α-synuclein–positive Lewy bodies in grafted neurons, providing the first evidence, to the authors' knowledge, that the disease can propagate from host to graft cells.
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Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up
M.C. Rodríguez-Oroz,Jose A. Obeso,Anthony E. Lang,J. L. Houeto,Pierre Pollak,Stig Rehncrona,Jaume Kulisevsky,Alberto Albanese,Jens Volkmann,Marwan Hariz,Niall Quinn,Johannes D. Speelman,Jorge Guridi,I Zamarbide,Alexandre Gironell,Joan Molet,Berta Pascual-Sedano,Bernard Pidoux,A M Bonnet,Yves Agid,Jing Xie,Alim-Louis Benabid,Andres M. Lozano,Jean A. Saint-Cyr,Luigi Romito,Maria Fiorella Contarino,Massimo Scerrati,Valérie Fraix,N. Van Blercom +28 more
TL;DR: This first multicentre study assessing the long-term efficacy of either STN or GPi stimulation shows a significant and substantial clinically important therapeutic benefit for at least 3-4 years in a large cohort of patients with severe Parkinson's disease.
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Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient
Paola Piccini,David J. Brooks,Anders Björklund,Roger N. Gunn,Paul M. Grasby,Ornella Rimoldi,Patrik Brundin,Peter Hagell,Stig Rehncrona,Håkan Widner,Olle Lindvall +10 more
TL;DR: Grafted neurons can continue for a decade to store and release dopamine and give rise to substantial symptomatic relief in a patient with Parkinson's disease.
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Brain lactic acidosis and ischemic cell damage: 1. Biochemistry and neurophysiology.
TL;DR: It is concluded that a high degree of tissue lactic acidosis during brain ischemia impairs postischemic recovery and that different degrees of tissue nacreous acidosis may explain why severe incomplete ischemIA, in certain experimental models, is more deleterious than complete brain is chemia.
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Dyskinesias following neural transplantation in Parkinson's disease
Peter Hagell,Paola Piccini,Anders Björklund,Patrik Brundin,Stig Rehncrona,Håkan Widner,Lesley Crabb,Nicola Pavese,Wolfgang H. Oertel,Niall Quinn,David J. Brooks,Olle Lindvall +11 more
TL;DR: Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by 18F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopamine neurons.