A
Alexandro Rodríguez-Rojas
Researcher at Free University of Berlin
Publications - 62
Citations - 2308
Alexandro Rodríguez-Rojas is an academic researcher from Free University of Berlin. The author has contributed to research in topics: Biology & Antimicrobial peptides. The author has an hindex of 22, co-authored 51 publications receiving 1879 citations. Previous affiliations of Alexandro Rodríguez-Rojas include Spanish National Research Council.
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Journal ArticleDOI
β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity
Arnaud Gutierrez,Luisa Laureti,S. Crussard,Heni Abida,Alexandro Rodríguez-Rojas,Jesús Blázquez,Zeynep Baharoglu,Didier Mazel,F. Darfeuille,Jörg Vogel,Ivan Matic +10 more
TL;DR: It is shown that mutagenesis induced by subinhibitory concentrations of antibiotics is a genetically controlled process that should be taken into consideration for the development of more efficient antimicrobial therapeutic strategies.
Journal ArticleDOI
Antibiotics and antibiotic resistance: a bitter fight against evolution.
TL;DR: The state of knowledge on antibiotics as promoters of antibiotic resistance is reviewed, finding that under certain environmental conditions, subinhibitory concentrations of antimicrobials may increase the mutagenic effect of antibiotics.
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Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes.
Vanesa Gómez-Piña,Alessandra Soares-Schanoski,Alexandro Rodríguez-Rojas,Carlos del Fresno,Felipe García,María Teresa Vallejo-Cremades,Irene Fernández-Ruiz,Francisco Arnalich,Pablo Fuentes-Prior,Eduardo López-Collazo +9 more
TL;DR: It is concluded that metalloproteinases are responsible for shedding of the TREM-1 ectodomain through proteolytic cleavage of its long juxtamembrane linker.
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Antimicrobials as promoters of genetic variation
TL;DR: Recent advances concerning the selection of naturally occurring resistant variants and horizontal gene transfer processes and their relevance in the field of antibiotic resistance are reviewed and discussed.
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Molecular Mechanisms and Clinical Impact of Acquired and Intrinsic Fosfomycin Resistance
TL;DR: The mechanism of action and molecular mechanisms for the development of fosfomycin resistance, including the modification of the antibiotic target, reduced antibiotic uptake and antibiotic inactivation are analysed and the role of each pathway in clinical isolates is described.