Showing papers in "Nature Communications in 2013"
TL;DR: A method that uses gene expression signatures to infer the fraction of stromal and immune cells in tumour samples and prediction accuracy is corroborated using 3,809 transcriptional profiles available elsewhere in the public domain.
Abstract: Infiltrating stromal and immune cells form the major fraction of normal cells in tumour tissue and not only perturb the tumour signal in molecular studies but also have an important role in cancer biology. Here we describe 'Estimation of STromal and Immune cells in MAlignant Tumours using Expression data' (ESTIMATE)--a method that uses gene expression signatures to infer the fraction of stromal and immune cells in tumour samples. ESTIMATE scores correlate with DNA copy number-based tumour purity across samples from 11 different tumour types, profiled on Agilent, Affymetrix platforms or based on RNA sequencing and available through The Cancer Genome Atlas. The prediction accuracy is further corroborated using 3,809 transcriptional profiles available elsewhere in the public domain. The ESTIMATE method allows consideration of tumour-associated normal cells in genomic and transcriptomic studies. An R-library is available on https://sourceforge.net/projects/estimateproject/.
4,651 citations
TL;DR: The development of a high-performance low bandgap polymer that enables a solution processed tandem solar cell with certified 10.6% power conversion efficiency under standard reporting conditions, which is the first certified polymer solar cell efficiency over 10%.
Abstract: An effective way to improve polymer solar cell efficiency is to use a tandem structure, as a broader part of the spectrum of solar radiation is used and the thermalization loss of photon energy is minimized. In the past, the lack of high-performance low-bandgap polymers was the major limiting factor for achieving high-performance tandem solar cell. Here we report the development of a high-performance low bandgap polymer (bandgap 60% and spectral response that extends to 900 nm, with a power conversion efficiency of 7.9%. The polymer enables a solution processed tandem solar cell with certified 10.6% power conversion efficiency under standard reporting conditions (25 °C, 1,000 Wm(-2), IEC 60904-3 global), which is the first certified polymer solar cell efficiency over 10%.
2,708 citations
TL;DR: This work demonstrates the design of a sulphur-TiO(2) yolk-shell nanoarchitecture with internal void space to accommodate the volume expansion of sulphur, resulting in an intact TiO( 2) shell to minimize polysulphide dissolution.
Abstract: The practical performance of lithium–sulphur batteries is lower than expected because of polysulphide dissolution into the electrolyte over time. Seh et al. show that a yolk–shell nanoarchitecture is able to encapsulate sulphur cathode materials efficiently and thus allows over 1,000 charge/discharge cycles.
1,904 citations
TL;DR: A coulombic efficiency nearing 100% and long cycling stability are achieved, and the advantage of this electrolyte is further demonstrated that lithium polysulphide dissolution is inhibited, thus overcoming one of today's most challenging technological hurdles.
Abstract: Commercial lithium-ion batteries normally use a liquid electrolyte. Suo et al. show that a glassy-like electrolyte containing a high concentration of lithium salt leads to a substantially enhanced battery performance because of suppressed formation of lithium dendrites on the lithium metal anodes.
1,892 citations
TL;DR: Intercalation of hydrazine, and its co-intercalation with N,N-dimethylformamide, resulted in increases of the c-lattice parameters of surface functionalized f-Ti3C2, from 19.5 to 25.48 and 26.8 Å, respectively.
Abstract: Intercalation and delamination of two-dimensional solids in many cases is a requisite step for exploiting their unique properties. Herein we report on the intercalation of two-dimensional Ti3C2, Ti3CN and TiNbC-so called MXenes. Intercalation of hydrazine, and its co-intercalation with N,N-dimethylformamide, resulted in increases of the c-lattice parameters of surface functionalized f-Ti3C2, from 19.5 to 25.48 and 26.8 A, respectively. Urea is also intercalated into f-Ti3C2. Molecular dynamics simulations suggest that a hydrazine monolayer intercalates between f-Ti3C2 layers. Hydrazine is also intercalated into f-Ti3CN and f-TiNbC. When dimethyl sulphoxide is intercalated into f-Ti3C2, followed by sonication in water, the f-Ti3C2 is delaminated forming a stable colloidal solution that is in turn filtered to produce MXene 'paper'. The latter shows excellent Li-ion capacity at extremely high charging rates.
1,876 citations
TL;DR: It is demonstrated that the flexible pressure-sensitive organic thin film transistors fabrication can be used for non-invasive, high fidelity, continuous radial artery pulse wave monitoring, which may lead to the use of flexible pressure sensors in mobile health monitoring and remote diagnostics in cardiovascular medicine.
Abstract: Flexible pressure sensors are essential parts of an electronic skin to allow future biomedical prostheses and robots to naturally interact with humans and the environment. Mobile biomonitoring in long-term medical diagnostics is another attractive application for these sensors. Here we report the fabrication of flexible pressure-sensitive organic thin film transistors with a maximum sensitivity of 8.4 kPa(-1), a fast response time of 15,000 cycles and a low power consumption of <1 mW. The combination of a microstructured polydimethylsiloxane dielectric and the high-mobility semiconducting polyisoindigobithiophene-siloxane in a monolithic transistor design enabled us to operate the devices in the subthreshold regime, where the capacitance change upon compression of the dielectric is strongly amplified. We demonstrate that our sensors can be used for non-invasive, high fidelity, continuous radial artery pulse wave monitoring, which may lead to the use of flexible pressure sensors in mobile health monitoring and remote diagnostics in cardiovascular medicine.
1,691 citations
TL;DR: This work demonstrates a scalable fabrication of graphene micro-supercapacitors over large areas by direct laser writing on graphite oxide films using a standard LightScribe DVD burner, which demonstrates a power density among the highest values achieved for any supercapacitor.
Abstract: Microscale supercapacitors are promising alternative energy-storage devices; however, their use has been limited by the need for complicated fabrication techniques. This work reports the scalable fabrication of graphene supercapacitors with planar geometry that achieve power densities of up to 200 W cm−3.
1,619 citations
TL;DR: Here, a critical instability in mesoporous TiO₂-sensitized solar cells arising from light-induced desorption of surface-adsorbed oxygen is identified and it is shown that this instability does not arise in mesosuperstructured solar cells.
Abstract: The power conversion efficiency of hybrid solid-state solar cells has more than doubled from 7 to 15% over the past year. This is largely as a result of the incorporation of organometallic trihalide perovskite absorbers into these devices. But, as promising as this development is, long-term operational stability is just as important as initial conversion efficiency when it comes to the development of practical solid-state solar cells. Here we identify a critical instability in mesoporous TiO₂-sensitized solar cells arising from light-induced desorption of surface-adsorbed oxygen. We show that this instability does not arise in mesoporous TiO₂-free mesosuperstructured solar cells. Moreover, our TiO₂-free cells deliver stable photocurrent for over 1,000 h continuous exposure and operation under full spectrum simulated sunlight.
1,569 citations
TL;DR: In this article, a route for the controlled synthesis of mesoporous polymer nanospheres, which can be further converted into carbon nanosphere through carbonization, is presented.
Abstract: The controlled synthesis of monodisperse nanospheres faces a number of difficulties, such as extensive crosslinking during hydrothermal processes. Here, the authors show a route for the controlled synthesis of mesoporous polymer nanospheres, which can be further converted into carbon nanospheres through carbonization.
1,542 citations
TL;DR: It is demonstrated that a single thin film of the low-temperature solution-processed organometal trihalide perovskite absorber CH3NH3PbI3-xClx, sandwiched between organic contacts can exhibit devices with power-conversion efficiency of up to 10% on glass substrates and over 6% on flexible polymer substrates.
Abstract: Organometal trihalide perovskite solar cells offer the promise of a low-cost easily manufacturable solar technology, compatible with large-scale low-temperature solution processing. Within 1 year of development, solar-to-electric power-conversion efficiencies have risen to over 15%, and further imminent improvements are expected. Here we show that this technology can be successfully made compatible with electron acceptor and donor materials generally used in organic photovoltaics. We demonstrate that a single thin film of the low-temperature solution-processed organometal trihalide perovskite absorber CH3NH3PbI3-xClx, sandwiched between organic contacts can exhibit devices with power-conversion efficiency of up to 10% on glass substrates and over 6% on flexible polymer substrates. This work represents an important step forward, as it removes most barriers to adoption of the perovskite technology by the organic photovoltaic community, and can thus utilize the extensive existing knowledge of hybrid interfaces for further device improvements and flexible processing platforms.
1,539 citations
TL;DR: Findings identify hnRNPA2B1 as a key player in miRNA sorting into exosomes and provide potential tools for the packaging of selected regulatory RNAs into exOSomes and their use in biomedical applications.
Abstract: Exosomes are released by most cells to the extracellular environment and are involved in cell-to-cell communication Exosomes contain specific repertoires of mRNAs, microRNAs (miRNAs) and other non-coding RNAs that can be functionally transferred to recipient cells However, the mechanisms that control the specific loading of RNA species into exosomes remain unknown Here we describe sequence motifs present in miRNAs that control their localization into exosomes The protein heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) specifically binds exosomal miRNAs through the recognition of these motifs and controls their loading into exosomes Moreover, hnRNPA2B1 in exosomes is sumoylated, and sumoylation controls the binding of hnRNPA2B1 to miRNAs The loading of miRNAs into exosomes can be modulated by mutagenesis of the identified motifs or changes in hnRNPA2B1 expression levels These findings identify hnRNPA2B1 as a key player in miRNA sorting into exosomes and provide potential tools for the packaging of selected regulatory RNAs into exosomes and their use in biomedical applications
TL;DR: The results show that the photogenrated electrons and holes can be separated between the different facets of semiconductor crystals, which may be useful in semiconductor physics and chemistry to construct highly efficient solar energy conversion systems.
Abstract: Charge separation is crucial for increasing the activity of semiconductor-based photocatalysts, especially in water splitting reactions. Here we show, using monoclinic bismuth vanadate crystal as a model photocatalyst, that efficient charge separation can be achieved on different crystal facets, as evidenced by the reduction reaction with photogenerated electrons and oxidation reaction with photogenerated holes, which take place separately on the {010} and {110} facets under photo-irradiation. Based on this finding, the reduction and oxidation cocatalysts are selectively deposited on the {010} and {110} facets respectively, resulting in much higher activity in both photocatalytic and photoelectrocatalytic water oxidation reactions, compared with the photocatalyst with randomly distributed cocatalysts. These results show that the photogenrated electrons and holes can be separated between the different facets of semiconductor crystals. This finding may be useful in semiconductor physics and chemistry to construct highly efficient solar energy conversion systems.
TL;DR: This work reports the unambiguous observation and electrostatic tunability of charging effects in positively charged, neutral and negatively charged excitons in field-effect transistors via photoluminescence and finds the charging energies for X(+) and X(-) to be nearly identical implying the same effective mass for electrons and holes.
Abstract: Monolayer group-VI transition metal dichalcogenides have recently emerged as semiconducting alternatives to graphene in which the true two-dimensionality is expected to illuminate new semiconducting physics. Here we investigate excitons and trions (their singly charged counterparts), which have thus far been challenging to generate and control in the ultimate two-dimensional limit. Utilizing high-quality monolayer molybdenum diselenide, we report the unambiguous observation and electrostatic tunability of charging effects in positively charged (X+), neutral (Xo) and negatively charged (X−) excitons in field-effect transistors via photoluminescence. The trion charging energy is large (30 meV), enhanced by strong confinement and heavy effective masses, whereas the linewidth is narrow (5 meV) at temperatures <55 K. This is greater spectral contrast than in any known quasi-two-dimensional system. We also find the charging energies for X+ and X− to be nearly identical implying the same effective mass for electrons and holes. Single layers of group-VI transition metal dichalcogenides have emerged as direct bandgap semiconductors in the two-dimensional limit. The authors show that monolayer molybdenum diselenide is an ideal system enabling electrostatic tunability of charging effects in neutral and charged electron-hole pairs, so-called excitons.
TL;DR: Ni et al. as discussed by the authors presented ultra-thin plasmonic holograms that control amplitude and phase in the visible region and are just 30 nm thick, which is comparable to the light wavelength used.
Abstract: Holographic techniques provide phase and amplitude information for images of objects, but normally the hologram thickness is comparable to the light wavelength used. Ni et al. present ultra-thin plasmonic holograms that control amplitude and phase in the visible region and are just 30 nm thick.
TL;DR: Infiltration of a conducting polymer hydrogel into Si-based anodes results in a well-connected three-dimensional network structure consisting of Si nanoparticles conformally coated by the conducting polymer, demonstrating a cycle life of 5,000 cycles with over 90% capacity retention at current density.
Abstract: Silicon has a high-specific capacity as an anode material for Li-ion batteries, and much research has been focused on overcoming the poor cycling stability issue associated with its large volume changes during charging and discharging processes, mostly through nanostructured material design. Here we report incorporation of a conducting polymer hydrogel into Si-based anodes: the hydrogel is polymerized in-situ, resulting in a well-connected three-dimensional network structure consisting of Si nanoparticles conformally coated by the conducting polymer. Such a hierarchical hydrogel framework combines multiple advantageous features, including a continuous electrically conductive polyaniline network, binding with the Si surface through either the crosslinker hydrogen bonding with phytic acid or electrostatic interaction with the positively charged polymer, and porous space for volume expansion of Si particles. With this anode, we demonstrate a cycle life of 5,000 cycles with over 90% capacity retention at current density of 6.0 A g(-1).
TL;DR: The results indicate that the gap between cell lines and tumours can be bridged by genomically informed choices of cell line models for all tumour types.
Abstract: Cancer cell lines are frequently used as in vitro tumour models. Recent molecular profiles of hundreds of cell lines from The Cancer Cell Line Encyclopedia and thousands of tumour samples from the Cancer Genome Atlas now allow a systematic genomic comparison of cell lines and tumours. Here we analyse a panel of 47 ovarian cancer cell lines and identify those that have the highest genetic similarity to ovarian tumours. Our comparison of copy-number changes, mutations and mRNA expression profiles reveals pronounced differences in molecular profiles between commonly used ovarian cancer cell lines and high-grade serous ovarian cancer tumour samples. We identify several rarely used cell lines that more closely resemble cognate tumour profiles than commonly used cell lines, and we propose these lines as the most suitable models of ovarian cancer. Our results indicate that the gap between cell lines and tumours can be bridged by genomically informed choices of cell line models for all tumour types.
TL;DR: The versatility of the perovskite structure is exploited to search for oxide catalysts that are both active and stable and can be explained by having the O p-band centre neither too close nor too far from the Fermi level, which is computed from ab initio studies.
Abstract: The electronic structure of transition metal oxides governs the catalysis of many central reactions for energy storage applications such as oxygen electrocatalysis. Here we exploit the versatility of the perovskite structure to search for oxide catalysts that are both active and stable. We report double perovskites (Ln₀.₅Ba₀.₅)CoO(₃-δ) (Ln=Pr, Sm, Gd and Ho) as a family of highly active catalysts for the oxygen evolution reaction upon water oxidation in alkaline solution. These double perovskites are stable unlike pseudocubic perovskites with comparable activities such as Ba₀.₅Sr₀.₅Co₀.₈Fe₀.₂O(₃-δ) which readily amorphize during the oxygen evolution reaction. The high activity and stability of these double perovskites can be explained by having the O p-band centre neither too close nor too far from the Fermi level, which is computed from ab initio studies.
TL;DR: This work introduces a set of materials and design concepts for a rechargeable lithium ion battery technology that exploits thin, low modulus silicone elastomers as substrates, with a segmented design in the active materials, and unusual 'self-similar' interconnect structures between them.
Abstract: An important trend in electronics involves the development of materials, mechanical designs and manufacturing strategies that enable the use of unconventional substrates, such as polymer films, metal foils, paper sheets or rubber slabs. The last possibility is particularly challenging because the systems must accommodate not only bending but also stretching. Although several approaches are available for the electronics, a persistent difficulty is in power supplies that have similar mechanical properties, to allow their co-integration with the electronics. Here we introduce a set of materials and design concepts for a rechargeable lithium ion battery technology that exploits thin, low modulus silicone elastomers as substrates, with a segmented design in the active materials, and unusual ‘self-similar’ interconnect structures between them. The result enables reversible levels of stretchability up to 300%, while maintaining capacity densities of B1.1 mAh cm � 2 . Stretchable wireless power transmission systems provide the means to charge these types of batteries, without direct physical contact.
TL;DR: Huang et al. as mentioned in this paper developed ultrathin plasmonic metasurfaces to provide 3D optical holographic image reconstruction in the visible and near-infrared regions for circularly polarized light.
Abstract: Holographic techniques allow for the construction of 3D images by controlling the wave front of light beams. Huang et al. develop ultrathin plasmonic metasurfaces to provide 3D optical holographic image reconstruction in the visible and near-infrared regions for circularly polarized light.
TL;DR: By combining this state-of-the-art photoanode with an earth-abundant cobalt phosphate water-oxidation catalyst and a double- or single-junction amorphous Si solar cell in a tandem configuration, stable short-circuit water-splitting photocurrents of ~4 and 3 mA cm(-2) are achieved under 1 sun illumination.
Abstract: The photoactivity of metal oxide electrodes for water splitting is often limited by poor charge separation. Abdi et al. improve the solar-to-hydrogen efficiency in a hybrid device that comprises a gradient-doped bismuth vanadate photoanode and a double-junction amorphous silicon tandem solar cell.
TL;DR: Graphene-based in- plane interdigital micro-supercapacitors with an in-plane geometry with great promise for numerous miniaturized or flexible electronic applications are demonstrated.
Abstract: Micro-supercapacitors offer the advantage of high power density over lithium batteries and high energy density over electric capacitors, but integration of these advantages is yet to be achieved. Wu et al. develop a graphene-based in-plane micro-supercapacitor with ultrahigh power and energy densities.
TL;DR: The integrated electrochemical performance of the amorphous nickel hydroxide is commensurate with crystalline materials in supercapacitors, and these findings promote the application ofAmorphous nanostructures as advanced electrochemical pseudocapacitor materials.
Abstract: Nickel hydroxide is a promising material for capacitor electrodes and most research has focussed on the crystalline form. Here, the authors report that amorphous nickel hydroxide nanospheres, which may be synthesized relatively easily, also exhibit excellent integrated electrochemical performance.
TL;DR: It is shown that long-term treatment with metformin starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic.
Abstract: Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic. Treatment with metformin mimics some of the benefits of calorie restriction, such as improved physical performance, increased insulin sensitivity, and reduced low-density lipoprotein and cholesterol levels without a decrease in caloric intake. At a molecular level, metformin increases AMP-activated protein kinase activity and increases antioxidant protection, resulting in reductions in both oxidative damage accumulation and chronic inflammation. Our results indicate that these actions may contribute to the beneficial effects of metformin on healthspan and lifespan. These findings are in agreement with current epidemiological data and raise the possibility of metformin-based interventions to promote healthy aging.
TL;DR: It is demonstrated that G PR43-deficient mice are obese on a normal diet, whereas mice overexpressing GPR43 specifically in adipose tissue remain lean even when fed a high-fat diet.
Abstract: The gut microbiota affects nutrient acquisition and energy regulation of the host, and can influence the development of obesity, insulin resistance, and diabetes. During feeding, gut microbes produce short-chain fatty acids, which are important energy sources for the host. Here we show that the short-chain fatty acid receptor GPR43 links the metabolic activity of the gut microbiota with host body energy homoeostasis. We demonstrate that GPR43-deficient mice are obese on a normal diet, whereas mice overexpressing GPR43 specifically in adipose tissue remain lean even when fed a high-fat diet. Raised under germ-free conditions or after treatment with antibiotics, both types of mice have a normal phenotype. We further show that short-chain fatty acid-mediated activation of GPR43 suppresses insulin signalling in adipocytes, which inhibits fat accumulation in adipose tissue and promotes the metabolism of unincorporated lipids and glucose in other tissues. These findings establish GPR43 as a sensor for excessive dietary energy, thereby controlling body energy utilization while maintaining metabolic homoeostasis.
TL;DR: It is shown that directivity of the far-field radiation pattern of single silicon spheres can be strongly dependent on the light wavelength and the nanoparticle size.
Abstract: Directional light scattering by spherical silicon nanoparticles in the visible spectral range is experimentally demonstrated for the first time. These unique optical properties arise because of simultaneous excitation and mutual interference of magnetic and electric dipole resonances inside a single nanosphere. Such behaviour is similar to Kerker's-type scattering by hypothetic magneto-dielectric particles predicted theoretically three decades ago. Here we show that directivity of the far-field radiation pattern of single silicon spheres can be strongly dependent on the light wavelength and the nanoparticle size. For nanoparticles with sizes ranging from 100 to 200 nm, forward-to-backward scattering ratio above six can be experimentally obtained, making them similar to 'Huygens' sources. Unique optical properties of silicon nanoparticles make them promising for design of novel low-loss visible- and telecom-range metamaterials and nanoantenna devices.
TL;DR: Li et al. as mentioned in this paper constructed stable zinc-air batteries using novel catalysts for oxygen reduction and evolution reactions, but their realization is hampered by the lack of efficient and robust air catalysts.
Abstract: Metal-air batteries are promising for energy storage because of their high theoretical energy density, but their realization is hampered by the lack of efficient and robust air catalysts. Li et al. construct stable zinc-air batteries using novel catalysts for oxygen reduction and evolution reactions.
TL;DR: This work introduces a large area, flexible piezoelectric material that consists of sheets of electrospun fibres of the polymer poly[(vinylidenefluoride-co-trifluoroethylene] in order to enable ultra-high sensitivity for measuring pressure, even at exceptionally small values (0.1 Pa).
Abstract: Multifunctional capability, flexible design, rugged lightweight construction and self-powered operation are desired attributes for electronics that directly interface with the human body or with advanced robotic systems. For these applications, piezoelectric materials, in forms that offer the ability to bend and stretch, are attractive for pressure/force sensors and mechanical energy harvesters. Here, we introduce a large area, flexible piezoelectric material that consists of sheets of electrospun fibres of the polymer poly[(vinylidenefluoride-co-trifluoroethylene]. The flow and mechanical conditions associated with the spinning process yield free-standing, three-dimensional architectures of aligned arrangements of such fibres, in which the polymer chains adopt strongly preferential orientations. The resulting material offers exceptional piezoelectric characteristics, to enable ultra-high sensitivity for measuring pressure, even at exceptionally small values (0.1 Pa). Quantitative analysis provides detailed insights into the pressure sensing mechanisms, and establishes engineering design rules. Potential applications range from self-powered micro-mechanical elements, to self-balancing robots and sensitive impact detectors.
TL;DR: It is demonstrated that hepatic stellate cells give rise to 82-96% of myofibroblasts in models of toxic, cholestatic and fatty liver disease, and HSCs should be considered the primary cellular target for anti-fibrotic therapies across all types of liver disease.
Abstract: Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the lack of detailed knowledge about specific cellular contributors mediating fibrogenesis hampers the design of effective antifibrotic therapies. Different cellular sources, including tissue-resident and bone marrow-derived fibroblasts, pericytes and epithelial cells, have been suggested to give rise to myofibroblasts, but their relative contributions remain controversial, with profound differences between organs and different diseases. Here we employ a novel Cre-transgenic mouse that marks 99% of hepatic stellate cells (HSCs), a liver-specific pericyte population, to demonstrate that HSCs give rise to 82-96% of myofibroblasts in models of toxic, cholestatic and fatty liver disease. Moreover, we exclude that HSCs function as facultative epithelial progenitor cells in the injured liver. On the basis these findings, HSCs should be considered the primary cellular target for antifibrotic therapies across all types of liver disease.
TL;DR: In this paper, the authors report that tree species richness in production forests shows positive to positively hump-shaped relationships with multiple ecosystem services, including production of tree biomass, soil carbon storage, berry production and game production potential.
Abstract: Forests are of major importance to human society, contributing several crucial ecosystem services. Biodiversity is suggested to positively influence multiple services but evidence from natural systems at scales relevant to management is scarce. Here, across a scale of 400,000 km(2), we report that tree species richness in production forests shows positive to positively hump-shaped relationships with multiple ecosystem services. These include production of tree biomass, soil carbon storage, berry production and game production potential. For example, biomass production was approximately 50% greater with five than with one tree species. In addition, we show positive relationships between tree species richness and proxies for other biodiversity components. Importantly, no single tree species was able to promote all services, and some services were negatively correlated to each other. Management of production forests will therefore benefit from considering multiple tree species to sustain the full range of benefits that the society obtains from forests.
TL;DR: In the Methods section of this Article, the species of the tissue plasminogen activator secretory signal used in adenovirus vector construction was stated incorrectly and should have been given as human.
Abstract: Nature Communications 2: Article number: 601 (2011); Published: 20 December 2011; Updated: 19 September 2013. In the Methods section of this Article, the species of the tissue plasminogen activator secretory signal used in adenovirus vector construction was stated incorrectly and should have been given as human.