Showing papers in "Experimental Parasitology in 2007"

TL;DR: Treatment with oils and constituents demonstrated that they inhibit parasite growth, with clove essential being the most effective one.

TL;DR: A correlation between transcript abundance proteinase activity and parasitic success of M. incognita is shown, consistent with a reduction in feeding efficiency.

TL;DR: In vitro and in vivo activities of piperaquine in combination with RBx11160 and artemether demonstrated a slight tendency towards antagonism, suggesting that a RBx 11160-piperquine combination therapy in humans should allow each molecule to exert its full antimalarial effect.

TL;DR: This study represents the first report about the binding of plasminogen to Schistosoma sp.

TL;DR: The overall findings of the current study indicated that H. helix has a potential anthelmintic benefit and further in vitro and in vivo evaluation of the different parts and fractions is needed to make use of this plant for therapeutic purposes.

TL;DR: The effect of miltefosine in arsenite-resistant Leishmania donovani (Ld-As20) promastigotes displaying an MDR phenotype and overexpressing Pgp-like protein was investigated and results indicate that Ld- as20 is sensitive to milteFosine.

TL;DR: In vivo, the treatment with the essential oil cured all infested rabbits and no statistical differences were observed respect to the treated control group, and the untreated rabbits remained infested.

TL;DR: The role of the TGF-β signaling pathway in parasite development, host–parasite interactions and male–female interactions is reviewed and studies on signaling in schistosomes opens a new era for investigation of host–Parasite and male-female interactions.

TL;DR: The gene encoding alkaline phosphatase (SmAP) was targeted by exposing the parasites to dsRNA encoding part of the SmAP coding region, and both long dsRNAs as well as synthetic short inhibitory RNAs (siRNAs) are effective at eliciting SmAP gene suppression in cultured schistosomula and in adult males and females.

TL;DR: It is shown that the administration of 0.5 microM epimastigote major surface glycoinositolphospholipids (GIPLs) to the infected bloodmeal inhibits up to 90% parasite infection in Rhodnius prolixus.

TL;DR: A concise review of the already available data guided by a selection of recently generated stage-specific glycan profiles is presented, and implications and prospects of glycomics studies of schistosomes are discussed.

TL;DR: It is shown through phenotypic analysis of loss-of-function mutants that PPLP5 is equally essential for mosquito infection and subsequent parasite development is rescued if the midgut is bypassed by injection of ookinetes into the hemocoel.

TL;DR: Gomesin, an antimicrobial peptide isolated from the hemocytes of the spider Acanthoscurria gomesiana, reduced the number of oocysts of both Plasmodium species in Anopheles stephensi mosquitoes, and did not appear to affect the mosquitoes.

TL;DR: It is suggested that Treg proliferation might be causally associated with the suppression of Th1 responses during early malaria infection, leading to increase parasitemia and mortality in BALB/c mice, possibly in an IL-10-dependent manner.

TL;DR: This review summarizes recent studies suggesting tyrosine kinases as important factors for the regulation of female gonad development and takes advantage of the schistosome genome project to propose a model for theregulation of vitelline-cell production and differentiation.

TL;DR: It is recommended that natural feeding be used to infect mice when a consistent oral infection is desired, based on the inconsistency of infections initiated with oral gavage.

TL;DR: The goal was identifying genes that may be essential for H. glycines survival and would serve as an automated pipeline for RNAi studies to both study and control H. Glycine max.

TL;DR: The results showed that s.c. immunization of BALB/c mice with liposomal rLmSTI1 induced a significant protection against challenge and a significant lower parasite burden in spleen up to 14 weeks after challenge, which supports the possibility of using Liposomal Leishmania antigens as a vaccine.

TL;DR: Glycoproteins from PMM and hydrophobic proteins from epimastigotes are suggested to be important for the adhesion of the parasite to the posterior midgut cells of the vector.

TL;DR: The role of positive selection exerted by naturally acquired type- and variant-specific immunity in maintaining the observed levels of polymorphism is discussed and it is suggested that this is the most likely explanation for the significant excess of nonsynonymous nucleotide replacements found in dimorphic msp-2 domains.

TL;DR: The results suggest that Bm-ALT-2 protein vaccination regimen may be slightly better than prime-boost vaccine regimen and the mechanism of protection appears to be largely mediated by a Th2-biased response.

TL;DR: The AMA1 gene appears to generate a strong specific immune response and also provides effective protection against toxoplasmosis more than the MIC2, M2AP and BAG1 genes.

TL;DR: There is no single signature response to CQ at the transcript level in P. falciparum, and cell cycle changes appear to have a more pronounced effect on gene expression, given the striking contrast to similar studies in other model eukaryotic organisms.

TL;DR: PCR assays have potential for detecting malaria parasites in asymptomatic infections, in evaluation of malaria vaccine molecule candidates, for screening blood donors, especially in endemic areas, or even in monitoring malaria therapy.

TL;DR: This study aims to determine global developmentally regulated and stage-specific gene expression in Schistosoma mansoni using serial analysis of gene expression (SAGE), and presents a preliminary analysis of genes expressed during development and sexual differentiation in the mammalian host and during early larval development in the snail host.

TL;DR: The results demonstrated antigiardial activity of Mentha x piperita, indicating its potential value as therapeutic agent against G. lamblia infections.

TL;DR: Observations indicate a strong requirement for Th1 response in the development of immunity to C. parvum in the adult IL-12p40(-/-) mice, information that will be essential to further investigate the immune responses during infections and in theDevelopment of potential vaccine candidates.

TL;DR: It is concluded that parasite lysis and biofilm formation mechanisms are important for understanding parasite-microbiota interactions in the gut of insect vectors of trypanosomatids.

TL;DR: Results show that apoptosis is induced in vitro by NOs in E. histolytica and renders them incapable of surviving in hamster's livers.

TL;DR: It is suggested that Tregs may be activated by S. japonicum eggs and play a role in restoring immune disorders in TNBS-induced colitis of mice and the percentage of regulatory T-cells was increased in the spleens of egg-exposed mice with TNBS, compared to non-egg exposed animals.