A
Alican Gulsevin
Researcher at Vanderbilt University
Publications - 26
Citations - 184
Alican Gulsevin is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Chemistry & Biology. The author has an hindex of 4, co-authored 13 publications receiving 58 citations. Previous affiliations of Alican Gulsevin include University of Florida.
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Journal ArticleDOI
Molecular architecture of the human caveolin-1 complex
Erkan Karakas,Alican Gulsevin,Zhumaniyaz Mamatnabiyev,Chinenye D Wachuku,Guevara, María,Tekmez Kulu +5 more
TL;DR: In this article , the authors show that the human caveolin-1 complex is composed of 11 protomers organized into a tightly packed disc with a flat membrane-embedded surface.
Posted ContentDOI
Molecular architecture of the human caveolin-1 complex
Jason Porta,Bing Han,Alican Gulsevin,Jeong Min Chung,Yelena Peskova,Sarah Connolly,Hassane S. Mchaourab,Jens Meiler,Erkan Karakas,Anne K. Kenworthy,Melanie D. Ohi +10 more
TL;DR: Cryo-electron microscopy shows that the human caveolin-1 complex is composed of 11 protomers organized into a tightly packed disc with a flat membrane-embedded surface, and suggests a new mechanism for how membrane sculpting proteins interact with membranes.
Journal ArticleDOI
Allosteric Agonism of α7 Nicotinic Acetylcholine Receptors: Receptor Modulation Outside the Orthosteric Site.
Alican Gulsevin,Roger L. Papke,Clare Stokes,Sumanta Garai,Ganesh A. Thakur,Marta Quadri,Nicole A. Horenstein +6 more
TL;DR: The findings show a novel mode of agonism through an allosteric site in the extracellular domain of α7 nAChR, which is nearly abolished upon coapplication with the AA site–selective antagonist 2,3,5,6MP-TQS.
Journal ArticleDOI
Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107
Marta Quadri,Sumanta Garai,Ganesh A. Thakur,Clare Stokes,Alican Gulsevin,Nicole A. Horenstein,Roger L. Papke +6 more
TL;DR: Allosteric activation by B-973B appeared more protracted than that produced by GAT107, and B- 973B responses were relatively insensitive to the noncompetitive antagonist mecamylamine compared with GAT 107 responses.
Journal ArticleDOI
Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design
Clara T. Schoeder,Samuel Schmitz,Jared Adolf-Bryfogle,Alexander M. Sevy,Alexander M. Sevy,Jessica A. Finn,Jessica A. Finn,Marion F. Sauer,Marion F. Sauer,Nina G. Bozhanova,Benjamin K. Mueller,Amandeep K. Sangha,Jaume Bonet,Jonathan H. Sheehan,Georg Kuenze,Brennica Marlow,Shannon T. Smith,Hope Woods,Brian J. Bender,Cristina Martina,Diego del Alamo,Pranav Kodali,Alican Gulsevin,William R. Schief,Bruno E. Correia,James E. Crowe,Jens Meiler,Rocco Moretti +27 more
TL;DR: An overview of current protocols for antibody and antigen modeling using Rosetta can be found in this article, where the authors present a detailed tutorial for antibody structure prediction, docking, and design and antigen design strategies.