M
Marion F. Sauer
Researcher at Vanderbilt University
Publications - 6
Citations - 674
Marion F. Sauer is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Sequence space (evolution) & Protein design. The author has an hindex of 4, co-authored 6 publications receiving 304 citations. Previous affiliations of Marion F. Sauer include Vanderbilt University Medical Center.
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Journal ArticleDOI
Macromolecular modeling and design in Rosetta: recent methods and frameworks
Julia Koehler Leman,Brian D. Weitzner,Brian D. Weitzner,Steven M. Lewis,Steven M. Lewis,Jared Adolf-Bryfogle,Nawsad Alam,Rebecca F. Alford,Melanie L. Aprahamian,David Baker,Kyle A. Barlow,Patrick Barth,Patrick Barth,Benjamin Basanta,Brian J. Bender,Kristin Blacklock,Jaume Bonet,Jaume Bonet,Scott E. Boyken,Phil Bradley,Christopher Bystroff,Patrick Conway,Seth Cooper,Bruno E. Correia,Bruno E. Correia,Brian Coventry,Rhiju Das,René M. de Jong,Frank DiMaio,Lorna Dsilva,Roland L. Dunbrack,Alex Ford,Brandon Frenz,Darwin Y. Fu,Caleb Geniesse,Lukasz Goldschmidt,Ragul Gowthaman,Jeffrey J. Gray,Dominik Gront,Sharon L. Guffy,Scott Horowitz,Po-Ssu Huang,Thomas Huber,Timothy M. Jacobs,Jeliazko R. Jeliazkov,David K. Johnson,Kalli Kappel,John Karanicolas,Hamed Khakzad,Hamed Khakzad,Karen R. Khar,Sagar D. Khare,Firas Khatib,Alisa Khramushin,Indigo Chris King,Robert Kleffner,Brian Koepnick,Tanja Kortemme,Georg Kuenze,Brian Kuhlman,Daisuke Kuroda,Jason W. Labonte,Jason W. Labonte,Jason K. Lai,Gideon Lapidoth,Andrew Leaver-Fay,Steffen Lindert,Thomas W. Linsky,Nir London,Joseph H. Lubin,Sergey Lyskov,Jack Maguire,Lars Malmström,Lars Malmström,Lars Malmström,Enrique Marcos,Orly Marcu,Nicholas A. Marze,Jens Meiler,Rocco Moretti,Vikram Khipple Mulligan,Santrupti Nerli,Christoffer Norn,Shane O’Conchúir,Noah Ollikainen,Sergey Ovchinnikov,Michael S. Pacella,Xingjie Pan,Hahnbeom Park,Ryan E. Pavlovicz,Manasi A. Pethe,Brian G. Pierce,Kala Bharath Pilla,Barak Raveh,P. Douglas Renfrew,Shourya S. Roy Burman,Aliza B. Rubenstein,Marion F. Sauer,Andreas Scheck,Andreas Scheck,William R. Schief,Ora Schueler-Furman,Yuval Sedan,Alexander M. Sevy,Nikolaos G. Sgourakis,Lei Shi,Justin B. Siegel,Daniel-Adriano Silva,Shannon Smith,Yifan Song,Amelie Stein,Maria Szegedy,Frank D. Teets,Summer B. Thyme,Ray Yu-Ruei Wang,Andrew M. Watkins,Lior Zimmerman,Richard Bonneau +117 more
TL;DR: This Perspective reviews tools developed over the past five years in the Rosetta software, including over 80 methods, and discusses improvements to the score function, user interfaces and usability.
Journal ArticleDOI
Protocols for Molecular Modeling with Rosetta3 and RosettaScripts
Brian J. Bender,Alberto Cisneros,Amanda M. Duran,Jessica A. Finn,Darwin Y. Fu,Alyssa D. Lokits,Benjamin K. Mueller,Amandeep K. Sangha,Marion F. Sauer,Alexander M. Sevy,Gregory Sliwoski,Jonathan H. Sheehan,Frank DiMaio,Jens Meiler,Rocco Moretti +14 more
TL;DR: An overview of the Rosetta suite of biomacromolecular modeling software and a series of step-by-step tutorials that feature de novo folding, comparative modeling, loop construction, protein docking, small molecule docking, and protein design are shared.
Journal ArticleDOI
Structural basis for nonneutralizing antibody competition at antigenic site II of the respiratory syncytial virus fusion protein
Jarrod J. Mousa,Marion F. Sauer,Alexander M. Sevy,Jessica A. Finn,John T. Bates,Gabriela Alvarado,Hannah King,Leah B. Loerinc,Rachel H. Fong,Benjamin J. Doranz,Bruno E. Correia,Oleksandr Kalyuzhniy,Xiaolin Wen,Theodore S. Jardetzky,William R. Schief,Melanie D. Ohi,Jens Meiler,James E. Crowe,James E. Crowe +18 more
TL;DR: A nonneutralizing class of site II-specific mAbs that competed for binding with palivizumab to postfusion RSV F protein is described, and two classes of siteII-specific neutralizing mAbs are described, one of which escaped competition with nonneutralized mAbs.
Journal ArticleDOI
Multi-state design of flexible proteins predicts sequences optimal for conformational change.
Marion F. Sauer,Marion F. Sauer,Alexander M. Sevy,Alexander M. Sevy,James E. Crowe,Jens Meiler +5 more
TL;DR: It is demonstrated that the REstrained CONvergence (RECON) algorithm can simultaneously evaluate the sequence of large proteins that undergo substantial conformational changes and that sequence positions which require substantial changes in their local environment across an ensemble of conformations are more likely to be conserved.
Journal ArticleDOI
Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design
Clara T. Schoeder,Samuel Schmitz,Jared Adolf-Bryfogle,Alexander M. Sevy,Alexander M. Sevy,Jessica A. Finn,Jessica A. Finn,Marion F. Sauer,Marion F. Sauer,Nina G. Bozhanova,Benjamin K. Mueller,Amandeep K. Sangha,Jaume Bonet,Jonathan H. Sheehan,Georg Kuenze,Brennica Marlow,Shannon T. Smith,Hope Woods,Brian J. Bender,Cristina Martina,Diego del Alamo,Pranav Kodali,Alican Gulsevin,William R. Schief,Bruno E. Correia,James E. Crowe,Jens Meiler,Rocco Moretti +27 more
TL;DR: An overview of current protocols for antibody and antigen modeling using Rosetta can be found in this article, where the authors present a detailed tutorial for antibody structure prediction, docking, and design and antigen design strategies.